Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue
Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue
复制标题
DOI：
10.1016/j.jnutbio.2007.11.005
复制
发表时间：
2008-12-01
影响因子：
5.6
通讯作者：
Imaizumi, Kazuhiko
中科院分区：
文献类型：
--
作者：
Nomura, Sachiko;Ichinose, Takashi;Imaizumi, Kazuhiko
本研究的目的是确定茶儿茶素(TCS)的减肥作用是否与棕色脂肪组织(BAT)解偶联蛋白1(UCP1)的表达有关。将雄性SD大鼠分为4组，分别饲喂高脂饲料(HF；35%脂肪)、HF+0.5%TC(HFTC)、正常脂肪(NF；5%FAT)或NF+0.5%TC(NFTC)饲料8周。实验结束后，分离肾周、附睾部白色脂肪组织(WATS)和肩胛间蝙蝠。NFTC组肾周WAT重量显著低于NF组(NF：12.7+/-0.53g；NFTC：10.2+/-0.43g；P
The aim of the present study was to determine whether the antiobesity effects of tea catechins (TCs) are associated with the expression of uncoupling protein 1 (UCP1) in brown adipose tissue (BAT). Male Sprague-Dawley rats were fed a high-fat (HF; 35% fat) diet for 5 weeks, then divided into four groups and fed an HF, HF with 0.5% TC (HFTC), normal-fat (NF; 5% fat) or NF with 0.5% TC (NFTC) diet for 8 weeks. At the end of the experimental period, perirenal and epididymal white adipose tissues (WATs) and interscapular BAT were isolated. The NFTC group had significantly lower perirenal WAT weights than the NF group (NF: 12.7 +/- 0.53 g; NFTC: 10.2 +/- 0.43 g; P