Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study
Effects of mandibular advancement on brain activation during inspiratory loading in healthy subjects: a functional magnetic resonance imaging study
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DOI：
10.1152/japplphysiol.00169.2005
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发表时间：
2006-02-01
影响因子：
3.3
通讯作者：
Ohyama, K
中科院分区：
文献类型：
--
作者：
Hashimoto, K;Ono, T;Ohyama, K
口腔矫治器一直是阻塞性睡眠呼吸暂停患者的流行治疗选择。然而，关于如何通过这些矫治器的下颌前移来调节呼吸挑战引起的大脑激活的信息很少。我们假设下颌前移可能会减轻由呼吸应激引起的大脑激活。 12 名健康受试者通过阻力吸气负荷诱发呼吸应激。使用视觉模拟量表主观评估阻力吸气负荷期间下颌前移的影响。还通过使用血氧水平依赖性功能磁共振成像来客观评估这些效果。随着下颌前移，视觉模拟评分显着下降。与下颌前移相关的皮质失活局限于几个特定区域，包括左侧扣带回和双侧前额皮质。已知这些区域参与呼吸控制。我们的结果表明，根据主观和神经标准，使用口腔矫治器前移下颌似乎有助于减少呼吸应激。
Oral appliances have been a popular treatment option for subjects with obstructive sleep apnea. However, little information is available on how brain activation induced by respiratory challenge is modulated by mandibular advancement with these appliances. We hypothesized that the brain activation caused by respiratory stress may be alleviated by mandibular advancement. Respiratory stress was induced in 12 healthy subjects by resistive inspiratory loading. The effects of mandibular advancement during resistive inspiratory loading were assessed subjectively by using a visual analog scale. These effects were also evaluated objectively by using blood oxygenation level-dependent functional magnetic resonance imaging. The score for the visual analog scale significantly decreased with mandibular advancement. Cortical deactivation, in association with mandibular advancement, was localized to several specific regions, including the left cingulate gyrus and the bilateral prefrontal cortexes. These regions are known to be involved in respiratory control. Our results suggest that mandibular advancement with an oral appliance appears to be useful for reducing respiratory stress, based on both subjective and neuronal criteria.