Oral and intravenous methadone use: some clinical and pharmacokinetic aspects
Oral and intravenous methadone use: some clinical and pharmacokinetic aspects
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DOI：
10.1016/s0376-8716(98)00190-2
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发表时间：
1999-06-01
影响因子：
4.2
通讯作者：
Eap, CB
中科院分区：
文献类型：
--
作者：
Felder, C;Uehlinger, C;Eap, CB
对参加美沙酮注射试验的15名患者和口服美沙酮维持治疗的15名患者的样本进行了比较，这些患者承认注射了部分或全部美沙酮回家剂量，并与20名完全口服美沙酮的维持治疗患者进行了比较。本研究证实，一般健康状况越差，情绪、心理或精神问题的程度越高，非法药物的使用越多，与使用美沙酮静脉给药模式有关的就业和支持问题的数量也越多。正如预期的那样，由于肠壁代谢的分流和肝脏首过效应，静脉注射组的活性对映体(R)-美沙酮的浓度/剂量比较高(增加23%)。这一差异达到了几乎具有统计学意义的值(P=0.054)。这就提出了一个问题，一些静脉注射美沙酮的人是否会在不知不觉中寻求更高剂量的美沙酮的效果。(C)1999爱思唯尔爱尔兰科学有限公司。保留所有权利。
A sample of 15 patients participating in an injectable methadone trial and of 15 patients in an oral methadone maintenance treatment, who admitted injecting part or all of their methadone take-home doses, were compared to 20 patients in maintenance treatment who use methadone exclusively by mouth. The present study confirms the poorer general health, the higher levels of emotional, psychological or psychiatric problems, the higher use of illicit drugs, and the higher number of problems related to employment and support associated with the use of the intravenous mode of administration of methadone. As expected, due to the shunt of metabolism in the gut wall and of the liver first-pass effect, higher concentration to dose ratios of (R)-methadone, which is the active enantiomer, were measured in the intravenous group (23% increase). This difference reached an almost statistically significant value (P = 0.054). This raises the question whether the effect of a higher methadone dose could be unconsciously sought by some of the intravenous methadone users. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.