RECOVERY FROM MONOCULAR DEPRIVATION IN THE MONKEY .1. REVERSAL OF PHYSIOLOGICAL-EFFECTS IN THE VISUAL-CORTEX
RECOVERY FROM MONOCULAR DEPRIVATION IN THE MONKEY .1. REVERSAL OF PHYSIOLOGICAL-EFFECTS IN THE VISUAL-CORTEX
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DOI：
10.1098/rspb.1981.0072
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发表时间：
1981-01-01
期刊：
影响因子：
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通讯作者：
GAREY, LJ
中科院分区：
文献类型：
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作者：
BLAKEMORE, C;VITALDURAND, F;GAREY, LJ
研究了单眼剥夺、反向缝合（打开被剥夺的眼睛并关闭另一只眼睛）和单独重新打开被剥夺的眼睛（不关闭另一只眼睛）对猴子（Erythrocebus patas）初级视觉皮层生理组织的影响。所有动物最初从出生后不久直到大约20岁，通过缝合右眼睑而被剥夺单眼视力。 4 周龄（24-29 天）。在单眼剥夺动物中，在第 24 天时从区域 17 进行记录。 IVc 层外记录的大多数神经元都强烈或完全受左眼功能输入的支配。 IVc 层的非定向细胞（大部分传入输入终止于此）也主要由左眼控制。尽管两只眼睛的输入分离并不完全，但 IVc 层的大面积区域已经由左眼单眼控制。将动物 (4) 在 .apprx 处反向缝合。 4周并在3、6、15和126天后记录。在每只动物中，IVc 层内外的眼优势模式非常相似。即使仅强制使用最初被剥夺的右眼 3 天，.apprx。所记录的所有细胞中的 1/2 已被其控制，最初被剥夺的眼睛重新捕获皮质细胞的过程显然在 15 天内完成。在第四层，恢复的形式是由被剥夺的眼睛控制的区域扩大，就好像传入终端最初缩小的条纹已经扩大了。双眼驱动的神经元在所有阶段、所有层中都很罕见，但当存在且具有方向选择性时，它们在两只眼睛中具有相似的首选方向。同样，当从一只眼睛占主导地位的区域转移到另一只眼睛占主导地位的区域时，首选方向的柱状序列继续存在，没有明显的中断。只需在 .apprx 重新打开被剥夺的眼睛即可。 4 周，持续 15 或 96 天，导致皮质细胞的整体眼优势没有可检测到的变化，并且平均而言，IVc 层右眼优势柱没有扩张。反向缝合后的恢复不仅取决于携带右眼信息的轴突正常活动的恢复，还取决于通过使右眼比左眼更活跃来建立竞争优势。
The effects of monocular deprivation, reverse suturing (opening the deprived eye with closure of the other) and reopening of the deprived eye alone (without closing the other) on the physiological organization of the primary visual cortex in monkeys (Erythrocebus patas) were studied. All animals were initially monocularly deprived by suture of the lids of the right eye from soon after birth until .apprx. 4 wk of age (24-29 days). In a monocularly deprived animal, recordings were taken from area 17 at 24 days. Already most neurons recorded outside layer IVc were strongly or completely dominated by functional input from the left eye. The non-oriented cells of layer IVc, where the bulk of the afferent input terminates, were also mainly dominated by the left eye. Although segregation of input from the 2 eyes was not complete, large areas of layer IVc were already monocularly dominated by the left eye. Animals (4) were reverse-sutured at .apprx. 4 wk and recorded 3, 6, 15 and 126 days later. In each animal the pattern of ocular dominance was fairly similar within and outside layer IVc. Even with only 3 days of forced usage of the initially deprived right eye, .apprx. 1/2 of all cells recorded had become dominated by it, and the process of recapture of cortical cells by the initially deprived eye was apparently complete within 15 days. In layer IVc the recovery took the form of an expansion of zones dominated by the deprived eye, as if the originally shrunken stripes of afferent termination had become enlarged. Binocularly driven neurons were rare at all stages, in all layers, but when present and orientation-selective, they had similar preferred orientations in the 2 eyes. Likewise the columnar sequences of preferred orientation continued without obvious disruption on shifting from regions dominated by 1 eye to those dominated by the other. Simply reopening the deprived eye at .apprx. 4 wk for 15 or 96 days caused no detectable change in the overall ocular dominance of cortical cells and, on average, no expansion of right-eye dominance columns in layer IVc. The recovery seen after reverse suturing depends not just on the restoration of normal activity to axons carrying information from the right eye, but on the establishment of a competitive advantage, through the right eye being made more active than the left.