Subtype prevalence and baseline visual acuity by age in Japanese patients with neovascular age-related macular degeneration
Subtype prevalence and baseline visual acuity by age in Japanese patients with neovascular age-related macular degeneration
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DOI：
10.1007/s10384-023-00981-0
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发表时间：
2023-03-07
影响因子：
2.4
通讯作者：
Ohji，Masahito
中科院分区：
文献类型：
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作者：
Sawada，Tomoko;Yasukawa，Tsutomu;Ohji，Masahito
目的调查日本初治新生血管性年龄相关性黄斑变性 (nAMD) 患者的疾病亚型的年龄特异性患病率和基线最佳矫正视力 (BCVA)。研究设计回顾性多中心病例系列。方法我们回顾了 2006 年至 2015 年期间在日本 14 个机构接受初始治疗的初治 nAMD 患者的记录。在双眼接受治疗的患者中，仅首先治疗的眼睛被纳入分析。将患者按年龄分层进行分析。结果总共纳入3096只眼。各亚型的总体患病率如下：典型AMD，52.6%；息肉状脉络膜血管病变（PCV），42.8%；视网膜血管瘤增殖（RAP），4.6%。各年龄组眼数如下：60岁以下199眼；60岁以下199眼。 60 年代，747； 70 年代，1308； 80 年代，784； 90岁以上，58.各年龄组典型AMD患病率分别为51.8%、48.1%、52.1%、57.7%和55.2%。 PCV的患病率分别为46.7%、49.1%、44.7%、34.4%和19.0%。 RAP的患病率分别为1.5%、2.8%、3.2%、7.9%和25.9%。 PCV 的患病率随着年龄的增长而下降，而 RAP 的患病率则随着年龄的增长而增加。 90岁以上患者中RAP的患病率高于PCV。平均基线 BCVA (logMAR) 为 0.53。每个年龄组的平均基线 BCVA 分别为 0.35、0.45、0.54、0.62 和 0.88。基线时的平均logMAR BCVA随着年龄的增长而显着恶化（P<0.001）。结论日本患者中nAMD亚型的患病率根据年龄而不同。基线 BCVA 随着年龄的增长而恶化。
PurposeTo investigate age-specific prevalence of disease subtypes and baseline best-corrected visual acuity (BCVA) in Japanese patients with treatment-naïve neovascular age-related macular degeneration (nAMD).Study designRetrospective multicenter case series.MethodsWe reviewed the records of patients with treatment-naïve nAMD who underwent initial treatment in 14 institutions in Japan sometime during the period from 2006 to 2015. In patients in whom both eyes were treated, only the eye treated first was included for analysis. The patients were stratified by age for the analysis.ResultsIn total, 3096 eyes were included. The overall prevalence of subtypes was as follows: typical AMD, 52.6%; polypoidal choroidal vasculopathy (PCV), 42.8%; retinal angiomatous proliferation (RAP), 4.6%. The number of eyes in each age group was as follows: younger than 60 years, 199; 60s, 747; 70s, 1308; 80s, 784; 90 years or older, 58. The prevalence of typical AMD in each age group was 51.8%, 48.1%, 52.1%, 57.7%, and 55.2%, respectively. The prevalence of PCV was 46.7%, 49.1%, 44.7%, 34.4%, and 19.0%, respectively. The prevalence of RAP was 1.5%, 2.8%, 3.2%, 7.9%, and 25.9%, respectively. The prevalence of PCV decreased with age, whilst that of RAP increased. The prevalence of RAP was higher than that of PCV in patients aged 90 years or older. The mean baseline BCVA (logMAR) was 0.53. In each age group, the mean baseline BCVA was 0.35, 0.45, 0.54, 0.62, and 0.88, respectively. The mean logMAR BCVA at baseline significantly worsened with age (P< 0.001).ConclusionThe prevalence of nAMD subtypes differed according to age in Japanese patients. The baseline BCVA worsened with age.