Procedural learning and neostriatal dysfunction in man.
Procedural learning and neostriatal dysfunction in man.
复制标题
人类的程序学习和新纹状体功能障碍。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
A. Lang
中科院分区：
文献类型：
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作者：
J. Saint;A. Taylor;A. Lang
患有早期帕金森病的患者被证明在程序性学习的认知任务中选择性受损，而在陈述性记忆的回忆和识别测试中保持完整。相比之下，健忘症患者表现出相反的缺陷，从而证明了双重分离。早期亨廷顿舞蹈病患者与帕金森病患者或记忆缺失患者相似。在高级亨廷顿氏病组中，程序性学习和陈述性记忆均受损。有人认为，认知程序学习依赖于启发式策略的建立，通过涉及新纹状体和前额叶皮层回路的行动。
Patients with early stage Parkinson's disease are shown to be selectively impaired in a cognitive task of procedural learning while remaining intact in recall and recognition tests of declarative memory. In contrast, amnestic patients showed the opposite set of deficits, thus demonstrating a double dissociation. Patients with early Huntington's disease were either comparable to the parkinsonian patients or to amnestics. In the advanced Huntington's group, both procedural learning and declarative memory were impaired. It is argued that cognitive procedural learning depends on the establishment of heuristic strategies through the action of a circuit which involves the neostriatum and the prefrontal cortex.