Microwave-enhanced cadogan cyclization: An easy access to the 2-substituted carbazoles and other fused heterocyclic systems
Microwave-enhanced cadogan cyclization: An easy access to the 2-substituted carbazoles and other fused heterocyclic systems
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DOI：
10.1055/s-2004-836030
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发表时间：
2005-01-05
期刊：
影响因子：
2
通讯作者：
Dehaen, W
中科院分区：
文献类型：
--
作者：
Appukkuttan, P;Van der Eycken, E;Dehaen, W
微波增强的Suzuki-Miyaura交叉偶联反应与微波辅助的Cadogan还原环化反应相结合，作为一个容易获得的各种2-取代的咔唑和其他稠合杂环系统。微波辐射被发现非常有用，在最大限度地减少在交叉偶联反应中的质子脱硼的问题，并提高还原环化的速率在一个戏剧性的方式。
A microwave-enhanced Suzuki-Miyaura cross-coupling reaction in combination with a microwave-assisted Cadogan reductive cyclization is presented as an easy access to a variety of 2-substituted carbazoles and other fused heterocyclic systems. Microwave irradiation was found very useful in minimizing the proto-deboronation issues in the cross-coupling reaction, and enhances the rate of reductive cyclization in a dramatic manner.