Review about gabapentin misuse, interactions, contraindications and side effects.
Review about gabapentin misuse, interactions, contraindications and side effects.
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DOI：
10.2147/jep.s124391
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发表时间：
2017-01-01
影响因子：
--
通讯作者：
Quintero, Gabriel C
中科院分区：
文献类型：
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作者：
Quintero, Gabriel C
目前的工作旨在审查加巴喷丁滥用的风险，其与其他药物的潜在相互作用，副作用和使用禁忌症。这篇评论共包括99篇传记参考文献（从1983年到2016年）。对PubMed进行了1983年1月至2016年12月的出版物检索。它包括与加巴喷丁误用、潜在相互作用、副作用和使用禁忌症相关的动物研究、临床研究、病例研究和综述。检索词为加巴喷丁、抗惊厥药和抗癫痫药。一般来说，加巴喷丁似乎有被滥用的风险，这是基于处方水平的增加、相关死亡、娱乐性滥用和更高剂量的自我给药。加巴喷丁滥用的主要原因如下：获得高，减轻阿片类戒断症状和增强美沙酮效应。与加巴喷丁相互作用的一些主要物质是吗啡、咖啡因、氯沙坦、依他尼酸、苯妥英、甲氟喹和氧化镁。加巴喷丁引起的一些副作用是致畸性、通气不足、呼吸衰竭和肌病。最后，报告一般禁忌使用加巴喷丁的条件，如重症肌无力和肌阵挛。
The current work is targeted to review the risks of gabapentin misuse, its potential interactions with other drugs, side effects and use contraindications. This review consists of a total of 99 biographical references (from the year 1983 to 2016). A publication search of PubMed was performed from January 1983 to December 2016. It included animal studies, clinical studies, case studies and reviews related to gabapentin misuse, potential interactions, side effects and use contraindications. The search terms were gabapentin, anticonvulsant and antiepileptic. In general, it seems that gabapentin has risks of being misused based on the increased level of prescriptions, related fatalities, recreational misuse and higher doses of self-administration. The main reasons for gabapentin misuse are as follows: getting high, alleviating opioid withdrawal symptoms and potentiating methadone effects. Some of the main substances that interact with gabapentin are morphine, caffeine, losartan, ethacrynic acid, phenytoin, mefloquine and magnesium oxide. Some of the side effects caused by gabapentin are teratogenicity, hypoventilation, respiratory failure and myopathy. Finally, reports in general contraindicate the use of gabapentin in conditions such as myasthenia gravis and myoclonus.