Enhancement of Bordetella parapertussis infection by Bordetella pertussis in mixed infection of the respiratory tract.
Enhancement of Bordetella parapertussis infection by Bordetella pertussis in mixed infection of the respiratory tract.
复制标题
呼吸道混合感染中百日咳博德特氏菌增强副百日咳博德特氏菌感染。
DOI：
10.1111/j.1574-695x.2011.00836.x
复制
发表时间：
2011
影响因子：
--
通讯作者：
Carbonetti,NicholasH
中科院分区：
文献类型：
--
作者：
Worthington,ZoeEV;VanRooijen,Nico;Carbonetti,NicholasH
百日咳（百日咳）的两种病因——百日咳和副百日咳之间的流行病学和致病关系尚不清楚。我们假设b。百日咳，由于其免疫抑制活性，可能增强b。百日咳感染时两种细菌同时存在于呼吸道感染。用小鼠鼻内接种模型检验了这种关系的动力学。小鼠呼吸道感染b。百日咳不仅因为b。百日咳、butB。parapertussissignificantly outcompetedB。百日咳这个模型。两种微生物的交错接种表明，b。在感染的早期阶段建立百日咳。b。百日咳单一感染，混合感染无影响。与pt -缺陷b混合感染。b。parapertussisinfection。有趣的是，气道巨噬细胞的消耗逆转了这两种生物之间的竞争关系，但中性粒细胞的消耗对混合感染orB没有影响。parapertussisinfection。我们得出结论：b。百日咳可通过PT的作用增强aB.百日咳感染，可能是通过对先天免疫的抑制作用。
The epidemiological and pathogenic relationship betweenBordetella pertussisandBordetella parapertussis, the two causes of whooping cough (pertussis), is unclear. We hypothesized thatB. pertussis, due to its immunosuppressive activities, might enhanceB. parapertussisinfection when the two species were present in a coinfection of the respiratory tract. The dynamics of this relationship were examined using the mouse intranasal inoculation model. Infection of the mouse respiratory tract byB. parapertussiswas not only enhanced by the presence ofB. pertussis, butB. parapertussissignificantly outcompetedB. pertussisin this model. Staggered inoculation of the two organisms revealed that the advantage forB. parapertussisis established at an early stage of infection. Coadministration of PT enhancedB. parapertussissingle infection, but had no effect on mixed infections. Mixed infection with a PT-deficientB. pertussisstrain did not enhanceB. parapertussisinfection. Interestingly, the depletion of airway macrophages reversed the competitive relationship between these two organisms, but the depletion of neutrophils had no effect on mixed infection orB. parapertussisinfection. We conclude thatB. pertussis, through the action of PT, can enhance aB. parapertussisinfection, possibly by an inhibitory effect on innate immunity.