GRASP55 facilitates autophagosome maturation under glucose deprivation.
GRASP55 facilitates autophagosome maturation under glucose deprivation.
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GRASP55 在葡萄糖剥夺下促进自噬体成熟。
DOI：
10.1080/23723556.2018.1494948
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发表时间：
2018
影响因子：
2.1
通讯作者：
Wang,Yanzhuang
中科院分区：
文献类型：
--
作者：
Zhang,Xiaoyan;Wang,Yanzhuang
在生长条件下，高尔基体重组堆积蛋白（GRASP 55/GORASP 2）通过形成反式寡聚体，起到“胶水”的作用，将邻近的高尔基体池固定在一起。在葡萄糖饥饿时，GRASP 55被脱-O-GlcNAc酰化，并作为膜系链发挥作用，通过与LC 3-II和LAMP 2的相互作用促进自噬体-溶酶体融合。
Under growth condition, the Golgi reassembly-stacking protein of 55 kDa (GRASP55)/GORASP2 serves as the “glue” to hold adjacent Golgi cisternae into stacks by formingtrans-oligomers. Upon glucose starvation, GRASP55 is de-O-GlcNAcylated and functions as a membrane tether to facilitate autophagosome-lysosome fusion through the interactions with LC3-II and LAMP2.