SWINE AS AN INVIVO MODEL FOR ELECTROPHYSIOLOGIC EVALUATION OF CARDIAC PACING PARAMETERS
SWINE AS AN INVIVO MODEL FOR ELECTROPHYSIOLOGIC EVALUATION OF CARDIAC PACING PARAMETERS
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DOI：
10.1111/j.1540-8159.1984.tb04885.x
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发表时间：
1984-01-01
影响因子：
1.8
通讯作者：
HUGHES, HC
中科院分区：
文献类型：
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作者：
BOWMAN, TA;HUGHES, HC
心脏起搏器和新电极、材料和设计的临床前研究大部分在犬中进行。然而，狗具有电生理学差异，这可能妨碍准确地转化为临床试验。本研究的目的是为心血管系统比任何非灵长类动物更接近人类的动物开发正常的电生理参数。猪的阈值（电压和电流）强度-持续时间曲线显示脉冲持续时间与阈值要求之间的反比关系与其他物种相同。在0.5 ms时，心房的能量需求是心室的3.5-5.5倍，电流需求是心室的两倍（2.04 mA vs 0.72 mA），电压需求是心室的两倍（0.75 mV vs 0.32 mV）。与心耳相比，猪的S-A结P波振幅上级（7.80 ± 1.80 mV vs 4.28 ± 2.27 mV），转换速率更快（1.30 ± 0.56 mV/ms vs 0.44 ± 0.50 mV/ms）。与右心室内膜R波相比，猪左心室心肌R波的振幅（19.00 ± 6.44 mV vs 10.70 ± 4.34 mV）和转换速率（1.60 ± 0.62 mV/ms vs 0.90 ± 0.30 mV/ms）显著更大。猪的电生理参数比狗更类似于人的电生理参数;因此，猪是用于电生理研究和起搏器设备测试的有用动物模型。
Pre‐clinical studies of cardiac pacemakers and new electrodes, materials, and designs are for the most part conducted in dogs. Dogs, however, have electrophysiological differences which may preclude accurate translation to clinical trials. The purpose of this study was to develop normal electrophysiological parameters for an animal whose cardiovascular system more closely resembles that of man than any nonprimate animal. The threshold (voltage and current) strength‐duration curves of the pig showed the same inverse relationship between the pulse duration and threshold requirements as other species. At 0.5 ms the atrium had 3.5–5.5 times greater energy requirements, over twice the current (2.04 mA vs 0.72 mA) and twice the voltage (0.75 mV vs 0.32 mV) requirements when compared to the ventricles. The pig's S‐A nodal P‐wave was superior in amplitude (7.80 ± 1.80 mV vs 4.28 ± 2.27 mV) and the slew rate was faster (1.30 ± 0.56 mV/ms vs 0.44 ± 0.50 mV/ms) compared to that of the atrial appendage. The pig's left ventricular myocardial R‐wave had significantly greater amplitude (19.00 ± 6.44 mVvs 10.70 ± 4.34 mV) and faster slew rate (1.60 ± 0.62 mV/ms vs 0.90 ± 0.30 mV/ms) compared to the right ventricular endocardial R‐wave. The electrophysiological parameters of the pig were more similar to those of man than the dog; therefore, the pig is a useful animal model for electrophysiological studies and the testing of pacemaker equipment.