Ontogeny of arousal.
Ontogeny of arousal.
复制标题
觉醒的个体发生。
DOI：
10.1097/01.wnp.0000141754.03598.dc
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
CHIMEStud
中科院分区：
文献类型：
--
作者：
Crowell,DavidH;Brooks,LeeJ;Corwin,Michael;Davidson-Ward,Sally;Hunt,CarlE;Kapuniai,LindaE;Neuman,MichaelR;Silvestri,Jean;Tinsley,Larry;Weese-Mayer,DebraE;DiFiore,Juliann;Peucker,Mark;Grove,JohnS;Pearce,JamesW;CHIMEStud
个体发生的觉醒数据构成了一个重要的补充，稀疏的文献自发神经元活动。这些数据表明，可测量的婴儿自发性觉醒（SA）与固有的振荡夹带发生在活跃的睡眠比在安静的睡眠相同的持续时间的六倍多，是可识别的人类神经生物学功能。这些SA与种族或民族、性别、睡眠总时间、活跃或安静睡眠时间百分比、早产状态、危及生命事件史、有兄弟姐妹死于婴儿猝死综合征（SIDS）或母亲在怀孕期间吸烟无关。作为可测量的神经生理学事件，SA确立了分子和摩尔水平研究的参数，重点关注几个关键领域：（1）与神经递质相关的SA的神经元控制;（2）作为SIDS高流行病学风险婴儿中发生的临床心肺事件的重要先行因素;（3）作为气质和执行认知功能的调节生物学因素;（4）可能与改变SA水平的治疗干预相关的发病率和死亡率影响。
Ontogeny of arousal data constitute a vital supplement to the sparse literature on spontaneous neuronal activity. These data demonstrate that measurable infant spontaneous arousals (SAs) with an inherent oscillatory entrainment occur six times more in active sleep than in quiet sleep of the same duration and are identifiable as a human neurobiologic function. These SAs are not significantly associated with race or ethnicity, gender, total hours spent sleeping, percent time spent in active or quiet sleep, preterm status, history of a life-threatening event, having had a sibling who died of sudden infant death syndrome (SIDS), or having had a mother who smoked during this pregnancy. As measurable neurophysiologic events, SAs establish parameters for research at molecular and molar levels focusing on several critical areas:(1) the neuronal control of SA related to neurotransmitters,(2) as a significant antecedent factor in clinical cardiorespiratory events occurring in infants at high epidemiologic risk for SIDS;(3) as a regulatory biologic factor underlying temperament and executive cognitive functioning, and (4) morbidity and mortality effects possibly related to therapeutic interventions that alter SA levels.