The long-term reliability of static and dynamic quantitative sensory testing in healthy individuals
The long-term reliability of static and dynamic quantitative sensory testing in healthy individuals
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DOI：
10.1097/j.pain.0000000000000901
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发表时间：
2017-07-01
期刊：
影响因子：
7.4
通讯作者：
Hush, Julia M.
中科院分区：
文献类型：
--
作者：
Marcuzzi, Anna;Wrigley, Paul J.;Hush, Julia M.
定量感觉测试（QST）已越来越多地用于调查在广泛的疼痛条件下的躯体感觉功能的改变。这些发现的解释是基于这样的假设，即这些措施是稳定的和可重复的。到目前为止，QST的信度已被调查短重测间隔。本研究的目的是调查健康人群多模态QST评估的长期可靠性，在4个月内进行了3次测试。42名健康人参加了这项研究。进行静态和动态测试，包括冷、热痛阈（CPT、HPT）、机械卷紧率（WUR）、压力痛阈（PPT）、两点辨别（TPD）和条件性疼痛调制（CPM）。分别采用重复测量方差分析、组内相关系数（ICCs 3，1）和测量值的SE（SEM）分析系统偏倚、相对可靠性和一致性。静态QST（CPT、HPT、PPT和TPD）显示出良好至极好的可靠性（ICC：0.68-0.90）。动态QST（WUR和CPM）显示了从差到好的可靠性（ICC：0.35-0.61）。随着时间的推移，观察到背部的机械QST（PPT和TPD）和CPM（P < 0.01）的显著线性下降。静态QST在4个月内保持稳定;然而，观察到机械QST随时间推移出现小幅系统性下降。动态QST随时间的推移表现出相当大的变异性，特别是CPM使用PPT作为测试刺激没有表现出足够的可靠性，这表明这种测试范式可能是有用的监测个人随着时间的推移。
Quantitative sensory tests (QSTs) have been increasingly used to investigate alterations in somatosensory function in a wide range of painful conditions. The interpretation of these findings is based on the assumption that the measures are stable and reproducible. To date, reliability of QST has been investigated for short test-retest intervals. The aim of this study was to investigate the long-term reliability of a multimodal QST assessment in healthy people, with testing conducted on 3 occasions over 4 months. Forty-two healthy people were enrolled in the study. Static and dynamic tests were performed, including cold and heat pain threshold (CPT, HPT), mechanical wind-up [wind-up ratio (WUR)], pressure pain threshold (PPT), 2-point discrimination (TPD), and conditioned pain modulation (CPM). Systematic bias, relative reliability and agreement were analysed using repeated measure analysis of variance, intraclass correlation coefficients (ICCs3,1) and SE of the measurement (SEM), respectively. Static QST (CPT, HPT, PPT, and TPD) showed good-to-excellent reliability (ICCs: 0.68-0.90). Dynamic QST (WUR and CPM) showed poor-to-good reliability (ICCs: 0.35-0.61). A significant linear decrease over time was observed for mechanical QST at the back (PPT and TPD) and for CPM (P < 0.01). Static QST were stable over a period of 4 months; however, a small systematic decrease over time has been observed for mechanical QST. Dynamic QST showed considerable variability over time; in particular, CPM using PPT as the test stimulus did not show adequate reliability, suggesting that this test paradigm may be less useful for monitoring individuals over time.