THE EFFECT OF ORALLY-ADMINISTERED MELATONIN ON THE SEASONALITY OF DEER PELAGE EXCHANGE, ANTLER DEVELOPMENT, LH, FSH, PROLACTIN, TESTOSTERONE, T3, T4, CORTISOL, AND ALKALINE-PHOSPHATASE
THE EFFECT OF ORALLY-ADMINISTERED MELATONIN ON THE SEASONALITY OF DEER PELAGE EXCHANGE, ANTLER DEVELOPMENT, LH, FSH, PROLACTIN, TESTOSTERONE, T3, T4, CORTISOL, AND ALKALINE-PHOSPHATASE
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DOI：
10.1111/j.1600-079x.1986.tb00756.x
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发表时间：
1986-01-01
影响因子：
10.3
通讯作者：
SCHAMS, D
中科院分区：
文献类型：
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作者：
BUBENIK, GA;SMITH, PS;SCHAMS, D
每天口服5毫克褪黑激素（M）给四只雄性白尾鹿，时间表模仿自然光周期的长度先减少，然后增加。结果表明：1）试验动物的换毛、鹿茸矿化、脱绒和发情行为提前50-55天; 2)催乳素（PRL）水平呈双峰曲线，峰值在5月和8月，相比之下，单峰曲线的控制（峰值在6月）。3)与对照组相比（6月与8月），M喂养鹿的FSH峰值水平提前2个月。4)两组的LH浓度在7月达到最大值，然而，在实验组中，LH水平下降速度比对照组快得多，然后在11月再次上升。5)饲喂M的巴克斯的睾酮（T）浓度比对照组提前2个月升高。6)褪黑激素处理对T3或T4的季节变化没有显著影响。7)在两组中均未观察到皮质醇的季节性节律，也未观察到M的明显影响。8)两组之间的碱性磷酸酶水平没有统计学差异，尽管实验巴克斯的浓度比对照组提前两个月急剧下降到基础水平。
Five milligrams of melatonin (M) per day was administered orally to four male white-tailed deer on a schedule that mimicked first decreasing and then increasing lengths of natural photoperiod. The following seasonal phenotypic and hormonal responses were observed: 1) Pelage exchange, antler mineralization, velvet shedding, and rutting behavior of experimental animals were advanced by 50-55 days. 2) Prolactin (PRL) levels exhibited a bimodal curve with peaks in May and August, as compared to a monomodal curve of controls (peak in June). 3) Peak FSH levels of M-fed deer were advanced 2 months as compared to controls (June vs August). 4) LH concentrations of both groups reached maxima in July; however, in the experimental group, LH levels declined much faster than in controls and then rose again in October-November. 5) Testosterone (T) concentrations of M-fed bucks were elevated 2 months ahead of controls. 6) Melatonin treatment had no significant effect on seasonal variation of T3, or T4. 7) No seasonal rhythm of cortisol was seen in either group and no detectable effect of M was evident. 8) No statistical differences in levels of alkaline phosphatase were seen between groups, although concentrations in experimental bucks sharply dropped to basal levels two months ahead of controls.