CHIKUNGUNYA VIRUS IN ENTEBBE AREA OF UGANDA - ISOLATIONS AND EPIDEMIOLOGY
CHIKUNGUNYA VIRUS IN ENTEBBE AREA OF UGANDA - ISOLATIONS AND EPIDEMIOLOGY
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DOI：
10.1016/0035-9203(71)90212-4
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发表时间：
1971-01-01
影响因子：
2.2
通讯作者：
SEMPALA, SDK
中科院分区：
文献类型：
--
作者：
MCCRAE, AWR;HENDERSON, BE;SEMPALA, SDK
以下内容主要基于作者的总结和结论。1968年在乌干达恩德培附近进行的主要是例行监测工作中，从人或蚊子身上分离出15株基孔肯雅病毒。其中包括3月至5月从寨卡森林采集的9株非洲蚊，3月从在寨卡森林工作的蚊子收集者处采集的1株，4月至6月从散布在恩德培半岛的患者家中采集的4株，以及6月从寨卡森林采集的1株fuscopenata（西奥）。4月至7月在恩德培镇附近加强了蚊虫收集工作，但未能进一步隔离。对1968年11月和1969年1月收集的小样本红尾猴（ascanius Cercopithecus schmidtï）和1969年8月至10月收集的更大样本的血清进行的血凝抑制试验显示，对基孔肯雅热免疫的发生率很高，表明它们最近与该病毒有关。有证据表明，在森林猴中发生了由a传播的密集动物流行病。由效率低下的病媒系统偶然传播给人类，这些病媒系统本身无法维持疫情。没有证据表明基孔肯雅病毒在两种动物流行病之间的5至8年或10年的间隔期间在恩德培地区存在，甚至以潜伏形式存在。寨卡病毒所表现出的类似但不一致的5至8年的周期性支持了这一观点，即这是森林猴种群免疫动态带来的内在周期性。对这种周期性的可能解释是，尽管有证据表明在更有限的地点出现了动物流行病，但病毒在更大的维护区域内接近全面平衡的地方性动物流行病状态。
The following is based largely on the authors' summary and conclusions. In the course of mainly routine surveillance work in the vicinity of Entebbe, Uganda, in 1968, 15 strains of chikungunya virus were isolated from man or mosquitos. These comprised nine strains fromAedes africanus(Theo.) collected from the Zika forest in March-May, one strain in March from a mosquito collector who had been working at the Zika forest, four strains in April-June.from patients whose homes were scattered over the Entebbe peninsula, and one strain fromMansonia fuscopennata(Theo.) collected at the Zika forest in June. Intensified mosquito collections in the immediate vicinity of Entebbe township from April to July failed to yield further isolations. Haemagglutination inhibition tests on the sera of a small sample of redtail monkeys (Cercopithecus ascanius schmidtï) collected in November 1968 and January 1969 and a larger sample collected in August-October 1969 revealed a high incidence of immunity to chikungunya, indicating their recent involvement with the virus. The evidence indicates that there was an intensive epizootic in forest monkeys transmitted byA. africanuswith incidental leakage to man by inefficient vector systems, which could not maintain an outbreak by themselves.There is no evidence that chikungunya virus is maintained within the Entebbe area, even in a latent form, during the intervals of 5 to 8 or 10 years between epizootics. The similar but not coincident periodicity of 5 to 8 years exhibited by Zika virus supports the view that this is an intrinsic perodicity brought about by the dynamics of immunity in forest monkey populations. The possible explanation of such periodicity is that the virus approaches an over-all balanced enzootic status within a larger maintenance area, despite the evidence of travelling epizootics at more limited sites.