Validating the boundary element method for forward and inverse EEG computations in the presence of a hole in the skull
Validating the boundary element method for forward and inverse EEG computations in the presence of a hole in the skull
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DOI：
10.1002/hbm.10061
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发表时间：
2002-11-01
影响因子：
4.8
通讯作者：
Oostendorp, TF
中科院分区：
文献类型：
--
作者：
Oostenveld, R;Oostendorp, TF
颅骨上的孔可能对 EEG 和 ERP 有很大影响。偶极子拟合等逆源建模技术需要精确的体积导体模型。如果存在的话，该模型应该包含孔，特别是当神经元发生器或电极靠近孔时，例如，在颅骨上部有环钻孔的情况下。边界元法（BEM）由于其效率和可用性，是目前使用真实头部模型进行反演计算的首选方法。我们使用仿真方法，通过将边界元法与无孔体积导体的解析解以及有孔体积导体的有限差分法 (FDM) 进行比较，研究了边界元法的精度。此外，我们还使用边界元法评估了空洞对正向和逆向计算结果的影响。没有孔的情况下，与解析模型相比，三球 BEM 模型的准确度高达 5-10%，而相应的 FDM 模型则有误差
Holes in the skull may have a large influence on the EEG and ERP. Inverse source modeling techniques such as dipole fitting require an accurate volume conductor model. This model should incorporate holes if present, especially when either a neuronal generator or the electrodes are close to the hole, e.g., in case of a trephine hole in the upper part of the skull. The boundary element method (BEM) is at present the preferred method for inverse computations using a realistic head model, because of its efficiency and availability. Using a simulation approach, we have studied the accuracy of the BEM by comparing it to the analytical solution for a volume conductor without a hole, and to the finite difference method (FDM) for one with a hole. Furthermore, we have evaluated the influence of holes on the results of forward and inverse computations using the BEM. Without a hole and compared to the analytical model, a three-sphere BEM model was accurate up to 5-10%, while the corresponding FDM model had an error