Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human Erythrocytes
Improved Murine Model of Malaria Using Plasmodium falciparum Competent Strains and Non-Myelodepleted NOD-scid IL2Rγnull Mice Engrafted with Human Erythrocytes
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DOI：
10.1128/aac.00519-09
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发表时间：
2009-10-01
影响因子：
4.9
通讯作者：
Angulo-Barturen, Inigo
中科院分区：
文献类型：
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作者：
Belen Jimenez-Diaz, Maria;Mulet, Teresa;Angulo-Barturen, Inigo
恶性疟疾的小鼠模型可能成为药物发现的重要工具。在这里，我们展示了植入人类红细胞的非骨髓耗竭NOD-SCID IL2R伽马(NULL)小鼠支持的感染负荷比移植NOD-SCIDβ2微球蛋白(NULL)小鼠支持的高达10倍。新模型被用于药物发现，并用于评估恶性疟原虫细胞色素BC(1)的选择性抑制剂4-吡啶酮的治疗效果。
Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2R gamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta 2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc(1).