Catalytic Deprotonative Functionalization of Propargyl Silyl Ethers with Imines
Catalytic Deprotonative Functionalization of Propargyl Silyl Ethers with Imines
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DOI：
10.1002/adsc.200800281
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发表时间：
2008-08
影响因子：
5.4
通讯作者：
H. Naka;Daiki Koseki;Y. Kondo
中科院分区：
文献类型：
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作者：
H. Naka;Daiki Koseki;Y. Kondo
利用磷腈碱（t- bu - p4碱）催化丙炔基硅醚与亚胺的无金属C-H功能化，在温和的条件下以中等至优异的产率提供了结构明确的多取代吡咯。还介绍了用硅烷基化乙炔、醛和亚胺进行一锅三组分反应的方法。
A metal-free, catalytic C-H functionalization of propargyl silyl ethers with imines using the phosphazene base (t-Bu-P 4 base) provides structurally defined multisubstituted pyrroles in modest to excellent yields under mild conditions. A one-pot, three-component reaction using silylated acetylenes, aldehydes, and imines is also presented.