Magnetic Resonance Spectroscopy in Myocardial Disease
Magnetic Resonance Spectroscopy in Myocardial Disease
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DOI：
10.1016/j.jcmg.2008.08.005
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发表时间：
2009-01-01
影响因子：
14
通讯作者：
Neubauer, Stefan
中科院分区：
文献类型：
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作者：
Hudsmith, Lucy E.;Neubauer, Stefan
磁共振波谱 (MRS) 是唯一用于研究体内心脏代谢的无创、非辐射暴露技术。 MRS 使用来自原子核的磁共振信号，例如 (31) 磷、(1) 氢和 (23) 钠，提供有关心肌的全面代谢和生化信息。该方法用途广泛，可以提供有关心脏代谢作用的代谢见解，特别是心脏能量学，在多种情况下，包括高血压、瓣膜病和缺血性心脏病、心力衰竭、心脏移植以及心肌病。该方法还可用于监测患者对治疗干预的反应：药物、手术或介入。当与心血管磁共振成像相结合时，MRS 可以从病理生理学角度深入了解心脏结构、功能、灌注和代谢之间的相互关系。然而，由于时空分辨率低以及再现性低，MRS目前主要用作研究工具。希望未来的技术发展和更高磁场强度（例如7-T）的使用可以使心脏MRS在临床实践中得到应用。 （J Am Coll Cardiol Img 2009；2:87-96）(C) 2009 年，美国心脏病学会基金会
Magnetic resonance spectroscopy (MRS) is the only noninvasive, nonradiation exposure technique for the investigation of cardiac metabolism in vivo. MRS uses magnetic resonance signals from nuclei, such as (31)phosphorus, (1)hydrogen, and (23)sodium, to provide comprehensive metabolic and biochemical information about cardiac muscle. This method is highly versatile and can provide metabolic insights into the role of cardiac metabolism, in particular, cardiac energetics, in a wide number of conditions, including hypertensive, valvular, and ischemic heart disease, heart failure, and cardiac transplantation, as well as cardiomyopathies. This method can also be used to monitor patient responses to therapeutic interventions: pharmacologic, surgical, or interventional. When combined with cardiovascular magnetic resonance imaging, MRS enables detailed pathophysiologic insights into the inter-relations among cardiac structure, function, perfusion, and metabolism. However, MRS is currently used primarily as a research tool because of low temporal and spatial resolution and low reproducibility. It is hoped that future technical developments and use of higher magnetic field strengths (such as 7-T) may enable application of cardiac MRS in clinical practice. (J Am Coll Cardiol Img 2009;2:87-96) (C) 2009 by the American College of Cardiology Foundation