The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk taking in men
The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk taking in men
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DOI：
10.1016/j.evolhumbehav.2008.11.001
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发表时间：
2009-03-01
影响因子：
5.1
通讯作者：
Campbell, Benjamin
中科院分区：
文献类型：
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作者：
Dreber, Anna;Apicella, Coren L.;Campbell, Benjamin
个体在金融风险厌恶上表现出显著的异质性。最近对双胞胎的研究表明，一些变异受到个体可遗传差异的影响。尽管如此，还没有研究调查与健康个体的金融风险承担相关的可能的遗传基因。在这里，我们考察了94名年轻男性的金融风险偏好是否与多巴胺受体D-4基因中7重复等位基因(7R+)的存在以及多巴胺受体D-2基因中Al等位基因(Al+)的存在之间存在关联。虽然我们没有发现Al等位基因与风险偏好之间的关联，但我们确实发现7R+男性比7R-男性更喜欢冒险。在承担金融风险的可遗传变异中，这种多态大约占20%。我们认为，7R等位基因的选择可能是为了一种与冒险相关的行为表型。这与之前的进化论解释是一致的，即选择该等位基因是为了与迁徙和男性竞争相关的行为，这两者都带有风险因素。(C)2009 Elsevier Inc.保留所有权利。
Individuals exhibit substantial heterogeneity in financial risk aversion. Recent work on twins demonstrated that some variation is influenced by individual heritable differences. Despite this, there has been no study investigating possible genetic loci associated with financial risk taking in healthy individuals. Here, we examined whether there is an association between financial risk preferences, elicited experimentally in a game with real monetary payoffs, and the presence of the 7-repeat allele (7R+) in the dopamine receptor D-4 gene as well as the presence of the Al allele (Al+) in the dopamine receptor D-2 gene in 94 young men. Although we found no association between the Al allele and risk preferences, we did find that 7R+ men are significantly more risk loving than 7R- men. This polymorphism accounts for roughly 20% of the heritable variation in financial risk taking. We suggest that selection for the 7R allele may be for a behavioral phenotype associated with risk taking. This is consistent with previous evolutionary explanations suggesting that selection for this allele was for behaviors associated with migration and male competition, both of which entail an element of risk. (C) 2009 Elsevier Inc. All rights reserved.