Pre- and Postnatal Exposure to Perfluorinated Compounds (PFCs)
Pre- and Postnatal Exposure to Perfluorinated Compounds (PFCs)
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DOI：
10.1021/es101184f
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发表时间：
2010-09-15
影响因子：
11.4
通讯作者：
Volkel, Wolfgang
中科院分区：
文献类型：
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作者：
Fromme, Hermann;Mosch, Christine;Volkel, Wolfgang
全氟化合物 (PFC) 是一组广泛用于多种应用的化学品。在这项研究中，我们对怀孕期间（两个时间点）（n = 40 和 38）和产后 6 个月（n = 47）的母血、脐带血（n = 33）以及出生后 6 个月（n = 40）和 19 个月（n = 24）的婴儿血液以及德国每月的母乳样本中的 PFC 进行了调查。母体血清中全氟辛烷磺酸（PFOS）的浓度范围为0.5至9.4μg/L，全氟辛酸（PFOA）的浓度范围为0.7至8.7μg/L。在脐带血清中，PFOS 和 PFOA 的值分别为 0.3 至 2.8 μg/L 和 0.5 至 4.2 μg/L。 6 个月和 19 个月龄血清中 PFOS 的中位结果分别为 3.0 和 1.9 μg/L，PFOA 的中位结果分别为 6.9 和 4.6 μg/L。在母乳样品中，全氟辛烷磺酸 (PFOS) 的含量范围为 < 0.03 至 0.11 微克/升（中位数：0.04 微克/升），而全氟辛酸 (PFOA) 与所有其他 PFC 一样，仅在部分样品中检测到。总体而言，我们发现脐带血清中的 PFC 水平较低，并且在婴儿生命的最初几个月内浓度有所增加。尽管母乳中的浓度较低，但这种摄入量导致六个月大时的身体负担与成人中发现的（PFOS）相似或更高（PFOA）。
Perfluorinated compounds (PFCs) are a group of chemicals widely used for many applications. In this study PFCs were investigated in maternal blood during pregnancy (at two time points) (n = 40 and 38) and 6 months after delivery (n = 47), in cord blood (n = 33) and in blood of infants six (n = 40) and nineteen months (n = 24) after birth, and monthly in breast milk samples in Germany. Concentrations in maternal serum ranged from 0.5 to 9.4 mu g/L for perfluorooctane sulfonate (PFOS) and 0.7 to 8.7 mu g/L for perfluorooctanoic acid (PFOA). In cord serum, the values ranged from 0.3 to 2.8 mu g/L and from 0.5 to 4.2 mu g/L for PFOS and PFOA, respectively. The median results from serum at six and nineteen months of age were 3.0 and 1.9 mu g/L for PFOS and 6.9 and 4.6 mu g/L for PFOA, respectively. In breast milk samples, PFOS ranged from < 0.03 to 0.11 mu g/L (median: 0.04 mu g/L), while PFOA was detected only in some samples as were all other PFCs. Overall, we found low levels of PFCs in cord sera and an increase in concentrations through the first months of infant life. Although the concentrations in breast milk were low, this intake led to a body burden at the age of six months similar to (PFOS) or higher than (PFOA) that found in adufts.