Are glycoproteins and glycosaminoglycans components of the eukaryotic genome?
Are glycoproteins and glycosaminoglycans components of the eukaryotic genome?
复制标题
糖蛋白和糖胺聚糖是真核基因组的组成部分吗？
作者：
G. Stein;R. Roberts;J. Davis;W. Head;J. Stein;C. Thrall;J. V. Veen;D. W. Welch
真核生物的基因组主要由DNA和一系列复杂而异质的蛋白质组成。证据正在迅速积累，表明这些染色体蛋白质在决定基因组的结构和功能特性方面很重要1 -6。除了涉及细胞遗传信息的包装7 -12之外，染色体蛋白质还提供有限的和确定的可用于转录的遗传序列13 -23。但基因组组分的具体性质和相互作用模式仍有待解决。我们在这里提出的证据表明，几个分子量类的染色体蛋白质是糖蛋白。此外，我们报告的协会糖胺聚糖，另一类含碳水化合物的大分子，与真核基因组。
THE eukaryotic genome is composed primarily of DNA and a complex and heterogeneous array of proteins. Evidence is rapidly accumulating to suggest that these chromosomal proteins are important in determining structural as well as functional properties of the genome1–6. In addition to being implicated in packaging of the cell's genetic information7–12, chromosomal proteins render limited and defined genetic sequences available for transcription13–23. But the specific properties and mode of interaction of genome components remain to be resolved. We present here evidence that several molecular weight classes of chromosomal proteins are glycoproteins. Furthermore, we report the association of glycosaminoglycans, another class of carbohydrate-containing macromolecules, with the eukaryotic genome.