Penicillium species as a rare isolate in tracheal granulation tissue: a case series.
Penicillium species as a rare isolate in tracheal granulation tissue: a case series.
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DOI：
10.1186/1752-1947-2-84
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发表时间：
2008-03-17
影响因子：
1
通讯作者：
Petrou MA
中科院分区：
文献类型：
--
作者：
Randhawa PS;Nouraei SR;Howard DJ;Sandhu GS;Petrou MA
肉芽组织形成是上气道狭窄治疗中的一个主要问题。我们报告两例因插管后气管狭窄而接受喉气管重建手术的患者，其气管肉芽组织常被青霉菌定植。我们认为，虽然大多数青霉菌不会引起侵袭性疾病，但它们可能是上呼吸道狭窄发生的一个促成因素。对两例复发性喉气管狭窄患者的气管肉芽组织进行了微生物和真菌学研究。在显微镜下观察到青霉菌属，并从气管肉芽组织中培养。两名患者均未生长出任何已知与气道肉芽组织形成相关的细菌。两性霉素B、伊曲康唑、氟胞嘧啶伏立康唑和卡泊芬净对两种分离株均具有高度活性。在喉气管重建术中，对于复发性气管肉芽组织的调查应包括真菌原因的调查。
Granulation tissue formation is a major problem complicating the treatment of upper airway stenosis. We present two cases of recurrent tracheal granulation tissue colonisation by Penicillium species in patients undergoing laryngotracheal reconstructive surgery for post-intubation tracheal stenosis. We believe that although most Penicillium species do not cause invasive disease they can be a contributory factor to the occurrence of upper airway stenosis. A microbiological and mycological study of tracheal granulation tissue in two patients with recurrent laryngotracheal stenosis was carried out. Penicillium species was seen microscopically and cultured from tracheal granulation tissue. Neither patient grew any bacteria known to be associated with airway granulation tissue formation. Amphotericin B, itraconazole, flucytosine voriconazole and caspofungin were highly active against both isolates. A search for a fungal cause should form part of the investigation for recurrent tracheal granulation tissue during laryngotracheal reconstruction.