Histological evolution of pleuroparenchymal fibroelastosis.
Histological evolution of pleuroparenchymal fibroelastosis.
复制标题
DOI：
10.1111/his.12554
复制
发表时间：
2015-03
期刊：
影响因子：
6.4
通讯作者：
Watanabe K
中科院分区：
文献类型：
--
作者：
Hirota T;Yoshida Y;Kitasato Y;Yoshimi M;Koga T;Tsuruta N;Minami M;Harada T;Ishii H;Fujita M;Nabeshima K;Nagata N;Watanabe K
目的探讨胸膜实质成纤维细胞增生症(PPFE)的组织学演变过程。我们检查了4例患者，这些患者接受了两次肺活检，或接受了肺手术活检并进行了尸检，其中第一次活检的组织学诊断不是PPFE，但第二次活检或尸检的诊断是PPFE。1例为细胞性间质性肺炎，2例为细胞性间质性肺炎，2例为细胞性间质性肺炎，3例为肉芽肿型，4例为急性肺损伤。病例1的非特异性间质性肺炎样组织学中已经存在间隔弹力纤维增生症，但要达到实变型胸膜下纤维弹力纤维增生症，还需要几年时间。在病例3中，胸膜下纤维弹力纤维增生症在第一次活检中已经存在，但程度很小。12年后，取而代之的是一条长带的纤维弹力纤维增生症。首次活检中观察到的间隔炎症、纤维化和空隙组织在3-12年内被较少的细胞性胸膜下纤维弹力纤维增生症所取代。间质性炎症或急性肺损伤可能是PPFE发生发展的第一步。
To investigate the histological evolution in the development of pleuroparenchymal fibroelastosis (PPFE). We examined four patients who had undergone surgical lung biopsy twice, or who had undergone surgical lung biopsy and had been autopsied, and in whom the histological diagnosis of the first biopsy was not PPFE, but the diagnosis of the second biopsy or of the autopsy was PPFE. The histological patterns of the first biopsy were cellular and fibrotic interstitial pneumonia, cellular interstitial pneumonia (CIP) with organizing pneumonia, CIP with granulomas and acute lung injury in cases 1, 2, 3, and 4, respectively. Septal elastosis was already present in the non-specific interstitial pneumonia-like histology of case 1, but a few additional years were necessary to reach consolidated subpleural fibroelastosis. In case 3, subpleural fibroelastosis was already present in the first biopsy, but only to a small extent. Twelve years later, it was replaced by a long band of fibroelastosis. The septal inflammation and fibrosis and airspace organization observed in the first biopsies were replaced by less cellular subpleural fibroelastosis within 3–12 years. Interstitial inflammation or acute lung injury may be an initial step in the development of PPFE.
登录
查看更多内容
影响因子：
0.2
作者：
Watanabe K
通讯作者：
Watanabe K
影响因子：
3.1
作者：
Enomoto N;Kusagaya H;Oyama Y;Kono M;Kaida Y;Kuroishi S;Hashimoto D;Fujisawa T;Yokomura K;Inui N;Nakamura Y;Suda T
通讯作者：
Suda T
影响因子：
24.3
作者：
Reddy, Taryn L.;Tominaga, Masaki;Nicholson, Andrew G.
通讯作者：
Nicholson, Andrew G.
DOI：
10.1164/ajrccm.158.5.9803115
发表时间：
1998-11-01
影响因子：
24.7
作者：
Yokoyama, A;Kohno, N;Hiwada, K
通讯作者：
Hiwada, K
影响因子：
7.5
作者：
Ofek, Efrat;Sato, Masaaki;Hwang, David M.
通讯作者：
Hwang, David M.