Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition.
Infant gut strain persistence is associated with maternal origin, phylogeny, and traits including surface adhesion and iron acquisition.
复制标题
DOI：
10.1016/j.xcrm.2021.100393
复制
发表时间：
2021-09-21
期刊：
影响因子：
--
通讯作者：
Banfield JF
中科院分区：
文献类型：
--
作者：
Lou YC;Olm MR;Diamond S;Crits-Christoph A;Firek BA;Baker R;Morowitz MJ;Banfield JF
Gut microbiome succession affects infant development. However, it remains unclear what factors promote persistence of initial bacterial colonizers in the developing gut. Here, we perform strain-resolved analyses to compare gut colonization of preterm and full-term infants throughout the first year of life and evaluate associations between strain persistence and strain origin as well as genetic potential. Analysis of fecal metagenomes collected from 13 full-term and 9 preterm infants reveals that infants’ initially distinct microbiomes converge by age 1 year. Approximately 11% of early colonizers, primarily Bacteroides and Bifidobacterium, persist during the first year of life, and those are more prevalent in full-term, compared with preterm infants. Examination of 17 mother-infant pairs reveals maternal gut strains are significantly more likely to persist in the infant gut than other strains. Enrichment in genes for surface adhesion, iron acquisition, and carbohydrate degradation may explain persistence of some strains through the first year of life. Strain-resolved analysis shows 11% of bacteria persist during the first year of life Maternally acquired bacterial strains are more likely to persist in the infant gut Certain persisting strains are enriched with functions such as surface attachment Lou et al. use strain-resolved metagenomics to characterize preterm and full-term infant gut-microbiome succession during the first year of life. Approximately 11% of colonizing bacterial strains establish long-term residency, and many of these come from their mothers. Functions such as surface attachment may have facilitated retention in the gut.
登录
查看更多内容
影响因子：
28.3
作者：
Gibson, Molly K.;Wang, Bin;Ahmadi, Sara;Burnham, Carey-Ann D.;Tarr, Phillip I.;Warner, Barbara B.;Dantas, Gautam
通讯作者：
Dantas, Gautam
影响因子：
17.1
作者：
Arrieta, Marie-Claire;Stiemsma, Leah T.;Finlay, B. Brett
通讯作者：
Finlay, B. Brett
影响因子：
14.8
作者：
Doyle, Liam;Ovchinnikova, Olga G.;Whitfield, Chris
通讯作者：
Whitfield, Chris
影响因子：
11.8
作者：
Carl, Mike A.;Ndao, I. Malick;Tarr, Phillip I.
通讯作者：
Tarr, Phillip I.
影响因子：
16.6
作者：
Biggel M;Xavier BB;Johnson JR;Nielsen KL;Frimodt-Møller N;Matheeussen V;Goossens H;Moons P;Van Puyvelde S
通讯作者：
Van Puyvelde S