Creating and curing fatty hearts.
Creating and curing fatty hearts.
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DOI：
10.1097/mco.0b013e3283357272
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发表时间：
2010-03
影响因子：
3.1
通讯作者：
Goldberg IJ
中科院分区：
文献类型：
--
作者：
Khan RS;Drosatos K;Goldberg IJ
随着2型糖尿病和肥胖症发病率的增加，与脂质异位沉积相关的疾病正成为日益重要的医学问题。受脂毒性影响的器官之一是心脏，本文综述了对这个问题的人类和动物研究的最新进展。人体研究已明确表明心脏功能障碍与甘油三酯含量相关。最近，人类心脏样本已被用于评估与脂质积累改变相关的基因变化。基因改变的小鼠已经产生脂毒性心肌病，新的研究正在试图描绘治愈性疗法。人类研究将证实与脂毒性心肌病相关的代谢变化，希望动物研究将指导治疗方案。
Diseases associated with ectopic disposition of lipids are becoming an increasingly important medical problem as the incidence of type 2 diabetes and obesity increases. One of the organs affected by lipotoxicity is the heart and this review presents an update on human and animal studies of this problem. Human studies have clearly correlated heart dysfunction with the content of triglyceride. More recently human heart samples have been used to assess gene changes associated with altered lipid accumulation. Genetically altered mice have been created that develop lipotoxic cardiomyopathies and newer investigations are attempting to delineate curative therapies. Human studies will confirm the metabolic changes associated with lipotoxic cardiomyopathy and, hopefully, animal studies will guide treatment options.