NUTRITION AND CANCER - BACKGROUND AND RATIONALE OF THE EUROPEAN PROSPECTIVE INVESTIGATION INTO CANCER AND NUTRITION (EPIC)
NUTRITION AND CANCER - BACKGROUND AND RATIONALE OF THE EUROPEAN PROSPECTIVE INVESTIGATION INTO CANCER AND NUTRITION (EPIC)
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DOI：
10.1093/oxfordjournals.annonc.a058097
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发表时间：
1992-12-01
影响因子：
50.5
通讯作者：
RIBOLI, E
中科院分区：
文献类型：
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作者：
RIBOLI, E
讨论了近几十年来饮食与癌症流行病学研究的进展。除了一些关于富含水果和蔬菜的饮食对几种癌症的保护作用的一致数据外，关于饮食和癌症的回顾性病例对照研究提供的结果在许多重要问题上仍然相互矛盾，主要是饮食与乳腺癌之间的关系。建立大型前瞻性队列研究结合流行病学和实验室的方法，以扩大目前有限的知识的营养和相关因素在癌症病因学中的作用的理由。概述了欧洲癌症与营养前瞻性调查的主要特点。这项研究正在七个欧洲国家进行，将收集大约40万健康欧洲成年人的饮食，其他生活方式和环境因素，人体测量学以及生物样本的数据。将对受试者进行随访，以研究癌症的发病率和死亡率与流行病学数据和生化标志物的关系
The development of epidemiological research on diet and cancer during the last decades is discussed. Apart from some consistent data on the protection against several cancers conferred by a diet rich in fruits and vegetables, the results provided by retrospective case-control studies on diet and cancer remain contradictory on many important issues, and primarily on the relation between diet and breast cancer. The rationale is presented for setting up large prospective cohort studies combining epidemiological and laboratory methods in order to expand the presently limited knowledge of the role of nutrition and related factors in cancer etiology. The main features of the European Prospective Investigation into Cancer and Nutrition are outlined. The study is being carried out in seven European countries and it will collect data on diet, other lifestyle and environmental factors, anthropometry as well as biological samples in a cohort of about 400,000 healthy European adults. The subjects will be followed up to investigate the incidence of and mortality from cancer in relation to epidemiological data and biochemical markers