Critical brain regions for action recognition: lesion symptom mapping in left hemisphere stroke
Critical brain regions for action recognition: lesion symptom mapping in left hemisphere stroke
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DOI：
10.1093/brain/awq210
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发表时间：
2010-11-01
期刊：
影响因子：
14.5
通讯作者：
Coslett, Harry Branch
中科院分区：
文献类型：
--
作者：
Kalenine, Solene;Buxbaum, Laurel J.;Coslett, Harry Branch
关于左额下回、顶叶下回和颞中后回在动作识别中的作用，已经提出了一些相互矛盾的说法，部分原因是关于假设的镜像系统与观察到的和计划的动作相匹配的能力的持续辩论。我们报告了43名左半球中风患者在两项动作识别任务中的数据，在这两项任务中，他们听到和看到了一个动作词(锤击)，并从两个视频片段中选择了一个与该词对应的视频片段。在空间再认任务中，箔片存在身体姿势或运动幅度/时序的错误。在语义识别任务中，箔在语义上是相关的(锯)。参与者还执行了一项理解控制任务，要求将相同的动词与物体匹配(锤子)。使用控制理解控制任务和病变体积的回归分析，我们证明了语义手势识别任务的成绩是由后颞叶的损伤百分比来预测的，而空间手势识别任务是由顶下小叶的损伤百分比来预测的。基于全脑体素的病变症状映射分析表明，语义和空间手势识别任务分别与颞后中回和顶下小叶的受损体素有关。在动作和意义的联系中，后中回似乎是一个中心节点。顶下小叶被认为是猴子顶端镜像神经元系统的同源物，对于编码与物体相关的姿势和运动至关重要，这是手势识别的一个相对有限的方面。另一方面，额叶下回并不能预测在任何任务中的表现，这表明之前关于它在动作识别中的作用的说法可能需要改进。
A number of conflicting claims have been advanced regarding the role of the left inferior frontal gyrus, inferior parietal lobe and posterior middle temporal gyrus in action recognition, driven in part by an ongoing debate about the capacities of putative mirror systems that match observed and planned actions. We report data from 43 left hemisphere stroke patients in two action recognition tasks in which they heard and saw an action word ('hammering') and selected from two videoclips the one corresponding to the word. In the spatial recognition task, foils contained errors of body posture or movement amplitude/timing. In the semantic recognition task, foils were semantically related (sawing). Participants also performed a comprehension control task requiring matching of the same verbs to objects (hammer). Using regression analyses controlling for both the comprehension control task and lesion volume, we demonstrated that performance in the semantic gesture recognition task was predicted by per cent damage to the posterior temporal lobe, whereas the spatial gesture recognition task was predicted by per cent damage to the inferior parietal lobule. A whole-brain voxel-based lesion symptom-mapping analysis suggested that the semantic and spatial gesture recognition tasks were associated with lesioned voxels in the posterior middle temporal gyrus and inferior parietal lobule, respectively. The posterior middle temporal gyrus appears to serve as a central node in the association of actions and meanings. The inferior parietal lobule, held to be a homologue of the monkey parietal mirror neuron system, is critical for encoding object-related postures and movements, a relatively circumscribed aspect of gesture recognition. The inferior frontal gyrus, on the other hand, was not predictive of performance in any task, suggesting that previous claims regarding its role in action recognition may require refinement.