The behavioural patterns and neural correlates of concrete and abstract verb processing in aphasia: A novel verb semantic battery.
The behavioural patterns and neural correlates of concrete and abstract verb processing in aphasia: A novel verb semantic battery.
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DOI：
10.1016/j.nicl.2017.12.009
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Lambon Ralph MA
中科院分区：
文献类型：
--
作者：
Alyahya RSW;Halai AD;Conroy P;Lambon Ralph MA
通常，对于健康成年人和失语症患者来说，对具体概念的处理比抽象概念的处理更准确、更有效。虽然，具体性的影响已经被彻底记录在名词加工方面，其他的词类却很少受到关注，尽管它们往往不如名词具体。本研究旨在探讨卒中后失语症患者动词的具体-抽象差异及其神经相关性。鉴于动词理解测试的缺乏，本研究开发了一套神经心理学测试来评估具体和抽象动词的理解。具体来说，一个敏感的动词同义词判断测试，不同的项目的意象和频率，和一个图片到单词的匹配测试与许多具体的动词。然后收集规范性数据，并对48名慢性卒中后失语症患者进行测试，以探索动词处理的行为模式和神经相关性。结果显示，具体的理解比抽象的动词，符合现有的失语症文献名词处理。此外，患者在动词理解方面的表现优于动词产生。病变-症状相关分析揭示了支持具体和抽象动词加工的共同区域，包括左前颞叶、后缘上回和上级外侧枕叶皮质。它们之间的直接对比显示了其他地区的等级差异。具体而言，左额叶区域与处理抽象动词相关，而左后颞叶和枕叶区域与处理具体动词相关。此外，重叠和不同的神经相关被确定与具体动词的理解和生产。这些患者的发现与功能性神经成像和神经刺激的数据以及现有的语言组织模型相一致。开发了新的动词理解测试失语症中具体动词的加工比抽象动词更准确语义动词加工的神经相关物分布在左皮质区域具体和抽象动词加工之间的神经差异在产生和理解模式中观察到的神经差异
Typically, processing is more accurate and efficient for concrete than abstract concepts in both healthy adults and individuals with aphasia. While, concreteness effects have been thoroughly documented with respect to noun processing, other words classes have received little attention despite tending to be less concrete than nouns. The aim of the current study was to explore concrete-abstract differences in verbs and identify their neural correlates in post-stroke aphasia. Given the dearth of comprehension tests for verbs, a battery of neuropsychological tests was developed in this study to assess the comprehension of concrete and abstract verbs. Specifically, a sensitive verb synonym judgment test was generated that varied both the items' imageability and frequency, and a picture-to-word matching test with numerous concrete verbs. Normative data were then collected and the tests were administered to a cohort of 48 individuals with chronic post-stroke aphasia to explore the behavioural patterns and neural correlates of verb processing. The results revealed significantly better comprehension of concrete than abstract verbs, aligning with the existing aphasiological literature on noun processing. In addition, the patients performed better during verb comprehension than verb production. Lesion-symptom correlational analyses revealed common areas that support processing of concrete and abstract verbs, including the left anterior temporal lobe, posterior supramarginal gyrus and superior lateral occipital cortex. A direct contrast between them revealed additional regions with graded differences. Specifically, the left frontal regions were associated with processing abstract verbs; whereas, the left posterior temporal and occipital regions were associated with processing concrete verbs. Moreover, overlapping and distinct neural correlates were identified in association with the comprehension and production of concrete verbs. These patient findings align with data from functional neuroimaging and neuro-stimulation, and existing models of language organisation. Developed new verb comprehension tests Processing of concrete verbs is more accurate than abstract verbs in aphasia Neural correlates of semantic verb processing distributed in left cortical regions Graded neural difference between processing concrete and abstract verbs Graded neural differences observed in production and comprehension modalities
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DOI：
10.1523/jneurosci.3039-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bedny M;Caramazza A;Grossman E;Pascual-Leone A;Saxe R
通讯作者：
Saxe R
影响因子：
2
作者：
Cho-Reyes S;Thompson CK
通讯作者：
Thompson CK
影响因子：
3.2
作者：
Binder, JR;Westbury, CF;Medler, DA
通讯作者：
Medler, DA
影响因子：
3.5
作者：
Evans, Gemma A. L.;Ralph, Matthew A. Lambon;Woollams, Anna M.
通讯作者：
Woollams, Anna M.
DOI：
10.1037/0096-1523.10.3.340
发表时间：
1984-01-01
影响因子：
2.1
作者：
BALOTA, DA;CHUMBLEY, JI
通讯作者：
CHUMBLEY, JI