Role of LAT1 in the Promotion of Amino Acid Incorporation in Activated T Cells
Role of LAT1 in the Promotion of Amino Acid Incorporation in Activated T Cells
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DOI：
10.1615/critrevimmunol.2014011872
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发表时间：
2014-01-01
影响因子：
1.3
通讯作者：
Anzai, Naohiko
中科院分区：
文献类型：
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作者：
Hayashi, Keitaro;Anzai, Naohiko
从环境中摄取营养是细胞活动的基础。营养素的需求取决于细胞所处的环境。T细胞的激活改变了细胞代谢的结构和规模，这需要大量的营养物质。亲水性营养物质如葡萄糖和氨基酸不能扩散到细胞膜之外;因此需要转运蛋白来帮助这些营养物质进入细胞。基于这一观察，伴随T细胞活化的代谢变化必须与能够为细胞提供足够营养的转运蛋白的重组同时发生。本文综述了在活化T细胞中使用特殊营养转运蛋白的功能优势，并讨论了T细胞对营养饥饿的反应机制。
Intake of nutrients from the environment is fundamental to cellular activity. The requirement of nutrients depends on the situation in which cells are placed. Activation of T cells changes the structure and scale of cellular metabolism, which requires a large amount of nutrients. Hydrophilic nutrients such as glucose and amino acids cannot diffuse beyond the cellular membrane; thus transporters are required to assist the incorporation of these nutrients into cells. Based on this observation, metabolic changes accompanying activation of T cells must occur simultaneously with the reorganization of transporters that are capable of providing sufficient nutrients to the cell. This review describes the functional advantages of using special nutrient transporters in activated T cells and discusses the mechanisms of responses to nutrient starvation in T cells.