Synthesis of a C1-C23 fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.
Synthesis of a C1-C23 fragment of the archazolids and evidence for V-ATPase but not COX inhibitory activity.
复制标题
archazolid 的 C1-C23 片段的合成以及 V-ATP 酶而非 COX 抑制活性的证据。
DOI：
10.1055/s-0036-1588413
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Spiegel,PClint
中科院分区：
文献类型：
--
作者：
O'Neil,GregoryW;Craig,AlexanderM;Williams,JohnR;Young,JeffreyC;Spiegel,PClint
基于高产率的Stille偶联反应，完成了一个含C1-C23残基的咪唑类化合物的聚合合成，构建了取代的Z，Z，E-共轭三烯。去除保护基后，所得四醇显示出抑制空泡型ATP酶（V-ATP酶）但不抑制环氧合酶（考克斯）抑制活性的证据。
A convergent synthesis of a C1–C23fragment of the archazolids has been completed based on a high-yielding Stille coupling to construct the substitutedZ,Z,E-conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity.