Exercise Training Improves Plantar Flexor Muscle Function in mdx Mice
Exercise Training Improves Plantar Flexor Muscle Function in mdx Mice
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DOI：
10.1249/mss.0b013e31825703f0
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发表时间：
2012-09-01
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影响因子：
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通讯作者：
Lowe, Dawn A.
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文献类型：
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作者：
Baltgalvis, Kristen A.;Call, Jarrod A.;Lowe, Dawn A.
K.巴尔加尔维斯一、J. A.卡尔，G。D.科克伦河C.莱克YAN和D. A. LOWE。运动训练改善mdx小鼠的足底屈肌功能。医学科学体育锻炼：第44卷，第9期，第100页。1671-1679，2012。目的：我们检验了mdx小鼠低强度运动改善跖屈肌收缩功能、抗疲劳能力和线粒体适应性而不加重肌营养不良的假设。研究方法：我们对mdx小鼠进行了12周的自愿低阻力轮跑（Run，n = 17）或正常笼活动（久坐（Sed），n = 16），随后进行了足底屈肌扭矩生成和疲劳阻力或跑步机上的跑步能力的体内分析。进一步评估腓肠肌运动诱导的线粒体适应性和纤维类型分布和中央核。t检验用于确定Sed和Run组之间的差异。结果如下：与Sed mdx小鼠相比，Run小鼠的跖屈肌次最大等长扭矩和多个踝关节角度下的最大等长扭矩以及抗疲劳能力更强（P < 0.05）。Run组腓肠肌柠檬酸合成酶和β-羟酰辅酶A脱氢酶活性及细胞色素c氧化酶IV蛋白表达均高于Sed组（P
BALTGALVIS, K. A., J. A. CALL, G. D. COCHRANE, R. C. LAKER, Z. YAN, and D. A. LOWE. Exercise Training Improves Plantar Flexor Muscle Function in mdx Mice. Med. Sci. Sports Exerc., Vol. 44, No. 9, pp. 1671-1679, 2012. Purpose: We tested the hypothesis that low-intensity exercise in mdx mice improves plantar flexor muscle contractile function, resistance to fatigue, and mitochondrial adaptations without exacerbating muscular dystrophy. Methods: We subjected mdx mice to 12 wk of voluntary low-resistance wheel running (Run, n = 17) or normal cage activities (sedentary (Sed), n = 16) followed by in vivo analyses for plantar flexor torque generation and fatigue resistance or running capacity on a treadmill. Gastrocnemius muscles were further evaluated for exercise-induced mitochondrial adaptations and fiber type distribution and central nuclei. t-tests were used to determine differences between the Sed and Run groups. Results: Plantar flexor submaximal isometric torques and maximal isometric torque at multiple ankle joint angles and resistance to fatigue were greater in Run compared with Sed mdx mice (P < 0.05). Citrate synthase and beta-hydroxyacyl-CoA dehydrogenase enzyme activities and cytochrome c oxidase IV protein expression in gastrocnemius muscles were greater in Run than in Sed mdx mice (P