Cholinergic mechanisms in the nucleus tractus solitarii and cardiovascular regulation in the rat.
Cholinergic mechanisms in the nucleus tractus solitarii and cardiovascular regulation in the rat.
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DOI：
10.1016/0014-2999(83)90390-4
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发表时间：
1983-03
影响因子：
5
通讯作者：
L. Criscione;D. Reis;W. Talman
中科院分区：
文献类型：
--
作者：
L. Criscione;D. Reis;W. Talman
为探讨孤束核（NTS）胆碱能神经元在心血管调节中的作用，在大鼠孤束核内微量注射乙酰胆碱（ACh）或卡巴胆碱（C），记录血压和心率的变化。剂量依赖性低血压和心动过缓，导致介导的激活毒蕈碱，但不是烟碱，受体局限于NTS。双侧NTS中毒蕈碱受体的阻断会导致轻度高血压，并减弱但并未消除压力感受性反射。孤束核内注入乙丝氨酸，可增强和延长乙酰胆碱的作用，并轻微增加最大压力感受性反射反应。因此，NTS中的胆碱能机制往往会紧张性地降低动脉压，并可能调节压力感受器反射，而不是反射弧的组成部分。
To determine the role played by cholinergic neurons in cardiovascular regulation by the nucleus tractus solitarii (NTS), microinjections (0.1 μ1) of acetylcholine (ACh) or carbachol (C) were made into the NTS of rats, and the changes in arterial pressure and heart rate were recorded. The dose-dependent hypotension and bradycardia which resulted were mediated by the activation of muscarinic, but not nicotinic, receptors confined to the NTS. Blockade of muscarinic receptors bilaterally in the NTS resulted in mild hypertension and attenuated, but did not abolish, the baroreceptor reflex. Eserine, injected into the NTS, augmented and prolonged the action of acetylcholine and slightly increased the maximal baroreceptor reflex response. Thus, cholinergic mechanisms in the NTS tend tonically to lower arterial pressure and may modulate the baroreceptor reflex, without being an integral part of the reflex arc.