CD9 expression as a favorable prognostic marker for patients with malignant mesothelioma.
CD9 expression as a favorable prognostic marker for patients with malignant mesothelioma.
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DOI：
10.3892/or.2012.2116
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发表时间：
2013-01
期刊：
影响因子：
4.2
通讯作者：
Inai K
中科院分区：
文献类型：
--
作者：
Amatya VJ;Takeshima Y;Aoe K;Fujimoto N;Okamoto T;Yamada T;Kishimoto T;Morimoto C;Inai K
CD9参与细胞生长、粘附和运动，据报道其表达在各种类型的人类恶性肿瘤中具有预后意义。我们发现在体外shrna介导的CD9表达下调后，间皮瘤细胞系MSTO-211H和TUM1的细胞迁移增加。我们研究了112例恶性胸膜间皮瘤中CD9的表达。71例上皮样瘤中有62例，20例双相瘤中有13例，21例肉瘤样间皮瘤中仅有1例表达CD9。在上皮样间皮瘤（EMs）中，CD9在33例分化型（EM-D）和38例低分化型（EM-LD）中的29例中均有表达。CD9表达患者的1年和2年生存率（63%和25%）高于无CD9表达患者（39%和11%）。单因素分析显示，CD9表达的患者与其他临床病理因素（包括年龄小于60岁，IMIG分期I-II期，上皮样组织学，EM-D和接受胸膜外全肺切除术或化疗的患者）一起表现出更有利的生存率（P=0.0025）。多因素分析发现CD9表达是一个独立的预后因素，在所有间皮瘤分析中，其风险比（HR）为1.99 (P=0.0261)，在EMs分析中，其风险比（HR）为2.60 （P=0.0376）。CD9表达是恶性间皮瘤的独立预后有利标志。
CD9 is involved in cell growth, adhesion and motility and its expression is reported to be of prognostic significance in various types of human malignancies. We found increased cell migration in the mesothelioma cell lines MSTO-211H and TUM1 following in vitro shRNA-mediated knockdown of CD9 expression. We investigated CD9 expression in 112 malignant pleural mesotheliomas. CD9 expression was observed in 62 of 71 epithelioid, 13 of 20 biphasic and only 1 of 21 sarcomatoid mesotheliomas. Among the epithelioid mesotheliomas (EMs), CD9 expression was observed in all of the 33 cases with a differentiated type (EM-D) and in 29 of the 38 cases with a less-differentiated type (EM-LD). Patients with CD9 expression showed higher 1- and 2-year survival rates (63 and 25%) compared to the patients without CD9 expression (39 and 11%). Univariate analysis revealed that patients with CD9 expression demonstrated a more favorable survival (P=0.0025) along with other clinicopathological factors, including age younger than 60 years, IMIG stage I–II, epithelioid histology, EM-D and patients who underwent extrapleural pneumonectomy or received chemotherapy. Multivariate analysis identified CD9 expression as an independent prognostic factor with a hazard ratio (HR) of 1.99 in the analysis of all mesotheliomas (P=0.0261) and an HR of 2.60 in the analysis of EMs (P=0.0376). CD9 expression is an independent favorable prognostic marker of malignant mesothelioma.
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DOI：
10.1084/jem.177.5.1231
发表时间：
1993-05-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ikeyama S;Koyama M;Yamaoko M;Sasada R;Miyake M
通讯作者：
Miyake M
影响因子：
6.4
作者：
Jamil, F;Peston, D;Shousha, S
通讯作者：
Shousha, S
影响因子：
5.3
作者：
Kobayashi, Naruyuki;Toyooka, Shinichi;Date, Hiroshi
通讯作者：
Date, Hiroshi
影响因子：
11.2
作者：
Pass HI;Goparaju C;Ivanov S;Donington J;Carbone M;Hoshen M;Cohen D;Chajut A;Rosenwald S;Dan H;Benjamin S;Aharonov R
通讯作者：
Aharonov R
影响因子：
5.3
作者：
Gaafar, Rabab;Bahnassy, Abeer;Mokhtar, Nadia
通讯作者：
Mokhtar, Nadia