Potassium Channels Control the Interaction between Active Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons
Potassium Channels Control the Interaction between Active Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons
复制标题
DOI：
10.1016/j.neuron.2013.06.005
复制
发表时间：
2013-08-07
期刊：
影响因子：
16.2
通讯作者：
Williams, Stephen R.
中科院分区：
文献类型：
--
作者：
Harnett, Mark T.;Xu, Ning-Long;Williams, Stephen R.
主动树突突触整合增强了神经元的计算能力。这种非线性处理在感觉运动行为期间在5 B层皮质锥体神经元的顶端树突簇中产生对象定位信号。在这里，我们采用电生理和光学方法在脑切片和行为动物，以调查如何兴奋性突触输入到这个远端树突隔室影响神经元的输出。我们发现，整个顶端树突簇的活性树突整合是高度区室化的电压门控钾（KV）通道。高密度的瞬时和持续的K-V通道中观察到所有顶端树突状隔室。这些通道有力地调节顶端树突簇，躯干和轴体整合区之间的相互作用，以控制神经元的输出在体外以及在体内的树突的非线性处理在感觉运动行为的参与。因此，K-V通道动态地调节第5 B层锥体神经元中的活性树突整合区室之间的相互作用，以形成行为相关的神经元计算。
Active dendritic synaptic integration enhances the computational power of neurons. Such nonlinear processing generates an object-localization signal in the apical dendritic tuft of layer 5B cortical pyramidal neurons during sensory-motor behavior. Here, we employ electrophysiological and optical approaches in brain slices and behaving animals to investigate how excitatory synaptic input to this distal dendritic compartment influences neuronal output. We find that active dendritic integration throughout the apical dendritic tuft is highly compartmentalized by voltage-gated potassium (K-V) channels. A high density of both transient and sustained K-V channels was observed in all apical dendritic compartments. These channels potently regulated the interaction between apical dendritic tuft, trunk, and axosomatic integration zones to control neuronal output in vitro as well as the engagement of dendritic nonlinear processing in vivo during sensory-motor behavior. Thus, K-V channels dynamically tune the interaction between active dendritic integration compartments in layer 5B pyramidal neurons to shape behaviorally relevant neuronal computations.