Three New Indole Alkaloids from the Leaves of Alstonia scholaris
Three New Indole Alkaloids from the Leaves of Alstonia scholaris
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DOI：
10.1002/hlca.200590186
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发表时间：
2005-09
影响因子：
1.8
通讯作者：
Hua-Ying Zhou;Hong He;Xiao-Dong Luo;Yue-Hu Wang;Xianwen Yang;Y. Di;X. Hao
中科院分区：
文献类型：
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作者：
Hua-Ying Zhou;Hong He;Xiao-Dong Luo;Yue-Hu Wang;Xianwen Yang;Y. Di;X. Hao
3种新的吲哚类生物碱：5-甲氧基strictamine (=methyl (5 β,16R,19E)-5-甲氧基氨基-17-oate；1)，甲基(16R,19E)-1,2-二氢-16-（羟甲基）-5- oxoakammilan -17-oate(2)，甲基(2 β 16R,19E)-4,5-二脱氢-1,2-二氢-2-羟基-16-（羟甲基）akuammilan-4-ium-17-oate chloride(3)，与10个已知化合物一起从Alstonia scholaris叶片中分离得到。用光谱学方法测定了它们的结构。没有一种成分对WT细胞显示出显著的细胞毒活性。
Three new akuamillan-type indole alkaloids, i.e., 5-methoxystrictamine (=methyl (5 beta,16R,19E)-5-methoxyakuammilan-17-oate; 1), methyl (16R,19E)-1,2-dihydro-16-(hydroxymethyl)-5-oxoakuammilan-17-oate (2), and methyl (2 beta 16R,19E)-4,5-didehydro-1,2-dihydro-2-hydroxy-16-(hydroxymethyl)akuammilan-4-ium-17-oate chloride (3), have been isolated from the leaves of Alstonia scholaris, together with ten known compounds. Their structures were determined by spectroscopic means. None of the constituents showed significant cytotoxic activity towards WT cells.