First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia
First Preliminary Experience with Preservation of Liver Grafts from Extended-Criteria Donors by Normothermic Machine Perfusion in Asia
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DOI：
10.12659/aot.921529
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发表时间：
2020-04
影响因子：
1.1
通讯作者：
Zhiheng Zhang;W. Ju;Yunhua Tang;Linhe Wang;Caihui Zhu;Ningxin Gao;Qiang Zhao;Shanzhou Huang;Dong-ping Wang;Lu Yang;M. Han;W. Xiong;Lin-wei Wu;Maogen Chen;Yixi Zhang;Yanling Zhu;Chengjun Sun;Xiao-feng Zhu;Zhiyong Guo;Xiaoshun He
中科院分区：
文献类型：
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作者：
Zhiheng Zhang;W. Ju;Yunhua Tang;Linhe Wang;Caihui Zhu;Ningxin Gao;Qiang Zhao;Shanzhou Huang;Dong-ping Wang;Lu Yang;M. Han;W. Xiong;Lin-wei Wu;Maogen Chen;Yixi Zhang;Yanling Zhu;Chengjun Sun;Xiao-feng Zhu;Zhiyong Guo;Xiaoshun He
背景常温机器灌流(NMP)可以提供移植前评估和复苏高危供者肝脏的途径。本研究的目的是探讨核蛋白在中国扩大标准供者肝脏保存和评估中的作用。病例报告自2018年9月至2019年3月，对3个ECD移植中心的4例肝移植患者行NMP治疗，移植成功。在灌流过程中，记录灌流参数，如血管流量、血糖水平、乳酸清除率和胆汁生成/成分，以评估移植物的存活率。所有受者于移植后6个月随访。结论NMP为中国ECD肝脏的保存和评估提供了一种潜在的工具。
Background Normothermic machine perfusion (NMP) can provide access to evaluate and resuscitate high-risk donor livers before transplantation. The purpose of this study was to determine the efficacy of NMP in preservation and assessment of extended-criteria donor (ECD) livers in China. Case Reports From September 2018 to March 2019, 4 liver grafts from 3 transplant center defined as ECD were subjected to NMP, and then were transplanted successfully. During perfusion, perfusion parameters such as vascular flow, glucose level, lactate clearance, and bile production/composition were recorded to assess graft viability. All recipients were followed up 6 months after transplantation. Conclusions NMP provides a potential tool for preservation and assessment of ECD livers in China.