Indoor particulate matter and lung function in children
Indoor particulate matter and lung function in children
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DOI：
10.1016/j.scitotenv.2019.01.309
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发表时间：
2019-05-01
影响因子：
9.8
通讯作者：
Reponen, Tiina
中科院分区：
文献类型：
--
作者：
Isiugo, Kelechi;Jandarov, Roman;Reponen, Tiina
人们在室内呆的时间通常多于在室外的时间，因此室内颗粒物 (PM) 的暴露比例更高。因此，与室外 PM 水平相比，室内 PM 水平可能与肺功能有更强的关系。为了检验这一假设，我们同时从 44 名 10-16 岁哮喘儿童的家中收集了室内和室外 PM2.5 和真菌孢子数据。对收集的 PM2.5 质量采用光学吸收技术，以获得黑碳 (BC) 和紫外线吸收颗粒物（UVPM；阴燃有机物排放的光吸收 PM2.5 的标记）的浓度。进行环境测量后，登记的儿童完成了肺活量测定。鉴于 PM2.5、BC 和 UVPM 之间的高度相关性，采用主成分分析来获得测量 PM 的不相关摘要。开发了单独的线性混合效应模型来估计 PM 变量的主成分和肺活量测定值之间的关联，以及不相关的原始 PM 变量和肺活量测定值之间的关联。代表室内 PM（主要由 UVPM 和 PM2.5 组成）的第一主成分变量增加一个单位与 FEV1/FVC 比值下降 4.1% (99% CI=-6.9,-1.4) 相关。室内UVPM增加11.3μg/m(3)与预测FEV1/FVC比率和FEF25-75百分比分别下降6.4%和14.7%（分别为99% CI=-10.4、-2.4和99% CI=-26.3、-2.9）。此外，室内 PM2.5 增加 17.7 μg/m(3) 与预测 FEV1/FVC 比率和 FEF25-75 百分比分别下降 6.1% 和 12.9%（分别为 99% CI = -10.2、-1.9 和 99% CI = -24.9、-1.0）。室外PM、室内BC和室内真菌孢子与肺功能没有显着相关性。结果表明，与室外PM相比，室内PM与哮喘儿童肺功能的相关性更强。 (C) 2019 Elsevier B.V. 保留所有权利。
People generally spend more time indoors than outdoors resulting in a higher proportion of exposure to particulate matter (PM) occurring indoors. Consequently, indoor PM levels, in contrast to outdoor PM levels, may have a stronger relationship with lung function.To test this hypothesis, indoor and outdoor PM2.5 and fungal spore data were simultaneously collected from the homes of forty-four asthmatic children aged 10-16 years. An optical absorption technique was utilized on the collected PM2.5 mass to obtain concentrations of black carbon (BC) and ultraviolet light absorbing particulate matter, (UVPM; a marker of light absorbing PM2.5 emitted from smoldering organics). Enrolled children completed spirometry after environmental measurements were made. Given the high correlation between PM2.5, BC, and UVPM, principal component analysis was used to obtain uncorrelated summaries of the measured PM. Separate linear mixed-effect models were developed to estimate the association between principal components of the PM variables and spirometry values, as well as the uncorrelated original PM variables and spirometry values. A one-unit increase in the first principal component variable representing indoor PM(predominantly composed of UVPM and PM2.5) was associated with 4.1% decrease (99% CI=-6.9,-1.4) in FEV1/FVC ratio. 11.3 mu g/m(3) increase in indoor UVPM was associated with 6.4% and 14.7% decrease (99% CI=-10.4, -2.4 and 99% CI=-26.3, -2.9, respectively) in percent predicted FEV1/FVC ratio and FEF25-75 respectively. Additionally, 17.7 mu g/m(3) increase in indoor PM2.5 was associated with 6.1% and 12.9% decrease (99% CI = -10.2, -1.9 and 99% CI = -24.9, -1.0, respectively) in percent predicted FEV1/FVC ratio and FEF25-75, respectively. Outdoor PM, indoor BC, and indoor fungal spores were not significantly associated with lung function.The results indicate that indoor PM is more strongly associated with lung function in children with asthma as compared with outdoor PM. (C) 2019 Elsevier B.V. All rights reserved.