Alcohol consumption and cognitive function in the Whitehall II study
Alcohol consumption and cognitive function in the Whitehall II study
复制标题
DOI：
10.1093/aje/kwh206
复制
发表时间：
2004-08-01
影响因子：
5
通讯作者：
Marmot, M
中科院分区：
文献类型：
--
作者：
Britton, A;Singh-Manoux, A;Marmot, M
作者在一项英国队列研究（4，272名男性，1，761名女性）中调查了饮酒与认知功能之间的关系，中位随访时间为11年。在基线（1985-1988年）和随后的四个数据收集阶段获得了酒精消费量的测量结果。在第5阶段（1997-1999年）评估了认知功能（记忆测试、AH 4、Mill-Hill、语音和语义流畅性），当时参与者年龄为46-68岁。在过去一年中报告饮酒的人中，那些在过去一周内至少喝了一杯酒的人与那些没有喝的人相比，认知功能差的可能性明显降低。有益效果延伸到那些每周饮酒超过240克（约30杯）的人。这种影响对女性比男性更强，并且不限于那些有血管疾病证据的人。在横向和纵向分析中也发现了类似的关联。这种关系不能用吸烟和身心健康的混杂因素来解释，而且在很大程度上也不是由胆固醇或血压介导的。然而，当社会地位被加入模型时，这种关系被削弱了。作者得出的结论是，对于中年受试者来说，酒精消费水平的增加与认知某些方面的功能改善有关。尽管如此，并不建议将这些发现用于鼓励增加酒精消费。
The authors investigated the relation between alcohol consumption and cognitive function in a United Kingdom cohort study (4,272 men, 1,761 women) with median follow-up of 11 years. Measures of alcohol consumption were obtained at baseline (1985-1988) and four subsequent phases of data collection. Cognitive function (memory test, AH4, Mill-Hill, phonemic and semantic fluency) was assessed at phase 5 (1997-1999), when participants were aged 46-68 years. Of people who reported drinking alcohol in the past year, those who consumed at least one drink in the past week, compared with those who did not, were significantly less likely to have poor cognitive function. The beneficial effect extended to those drinking more than 240 g per week (approximately 30 drinks). The effect was stronger for women than men and was not confined to those with evidence of vascular disease. Similar associations were found in cross-sectional and longitudinal analyses. The relations were not explained by confounding by smoking and by physical and mental health and, to a large extent, were not mediated by cholesterol or blood pressure. However, the relations were weakened when social position was added to the model. The authors concluded that for middle-aged subjects, increasing levels of alcohol consumption were associated with better function regarding some aspects of cognition. Nonetheless, it is not proposed that these findings be used to encourage increased alcohol consumption.