Nanoprobes for Computed Tomography and Magnetic Resonance Imaging in Atherosclerosis Research.
Nanoprobes for Computed Tomography and Magnetic Resonance Imaging in Atherosclerosis Research.
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用于动脉粥样硬化研究中计算机断层扫描和磁共振成像的纳米探针。
DOI：
10.1007/978-1-0716-1924-7_49
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Annapragada,Ananth
中科院分区：
文献类型：
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作者：
Ghaghada,KetanB;Bhavane,Rohan;Badachhape,Andrew;Tanifum,Eric;Annapragada,Ananth
动脉粥样硬化性病变的特征是侵入血管管腔，导致血腔和血管壁的形态变化，导致内膜、中膜、外膜和周围组织的固体组织中出现特征性的分子和细胞特征。纳米探针可以很容易地形成，以提供长时间的血池停留和分子靶向，促进动脉粥样硬化变化的成像。纳米探针的检测可以通过多种方法来完成。在本章中，我们重点介绍横断面成像技术、计算机断层扫描(CT)和磁共振成像(MRI)的使用，这些技术有助于体内、非侵入性地成像动脉粥样硬化的血管形态和分子/细胞特征。所描述的方法适用于动物模型，尽管不同版本的探针正在为临床试验做准备，可能会促进未来的临床使用。
Atheromatous lesions are characterized by intrusion into the vascular lumen, resulting in morphological changes to the blood compartment and into the vessel wall, resulting in characteristic molecular and cellular signatures in the solid tissue of the intima, tunica media, adventitia and surrounding tissue. Nanoprobes can be easily formulated to provide long blood-pool residence and molecular targeting, facilitating the imaging of atheromatous changes. Detection of nanoprobes can be accomplished by a variety of methods. We focus in this chapter on the use of cross-sectional imaging techniques, computed tomography (CT) and magnetic resonance imaging (MRI), that facilitate in vivo, noninvasive imaging of the vascular morphology and molecular/cellular signatures of the atheroma. The methods described are suitable for use in animal models, although versions of the probes are being readied for clinical trials, potentially facilitating clinical use in the future.