Seasonal plasticity in the song control system - Multiple brain sites of steroid hormone action and the importance of variation in song behavior
Seasonal plasticity in the song control system - Multiple brain sites of steroid hormone action and the importance of variation in song behavior
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DOI：
10.1196/annals.1298.043
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Balthazart, J
中科院分区：
文献类型：
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作者：
Ball, GF;Auger, CJ;Balthazart, J
在非热带物种中，鸟鸣通常在春季和夏季更为常见，此时雄性会唱歌以吸引配偶和/或保卫领土。鸣唱控制核团，如HVC和arcopallium（RA）的强大的核团的体积的变化，观察季节性。春天长时间的光周期刺激睾丸的复发和睾丸激素的释放。雄激素受体和有时雌激素受体存在于HVC和RA中，作为促进这些受体的转录活性的辅因子。因此，睾酮可以直接作用于引起核体积的变化。然而，解离已被确定在时间长的光周期，最大浓度的睾酮，大的歌曲控制核，和高利率的歌曲。对这些分离的一种解释是，歌曲行为本身可以影响歌曲系统中的神经可塑性。Tehran可以通过脑源性神经营养因子（BDNF）发挥作用，该因子也可以在HVC中作为歌曲活动的结果而释放。睾酮可以通过作用于视前区来间接增加鸣唱核的体积，视前区是一个调节性行为（包括鸣唱）的区域，通过儿茶酚胺能细胞连接到鸣唱系统。歌曲系统中的季节性神经可塑性涉及季节状态、睾酮作用和行为活动之间的相互作用。
Birdsong, in non-tropical species, is generally more common in spring and summer when males sing to attract mates and/or defend territories. Changes in the volumes of song control nuclei, such as HVC and the robust nucleus of the arcopallium (RA), are observed seasonally. Long photoperiods in spring stimulate the recrudescence of the testes and the release of testosterone. Androgen receptors, and at times estrogen receptors, are present in HVC and RA as are co-factors that facilitate the transcriptional activity of these receptors. Thus testosterone can act directly to induce changes in nucleus volume. However, dissociations have been identified at times among long photoperiods, maximal concentrations of testosterone, large song control nuclei, and high rates of song. One explanation of these dissociations is that song behavior itself can influence neural plasticity in the song system. Testosterone can act via brain-derived neurotrophic factor (BDNF) that is also released in HVC as a result of song activity. Testosterone could enhance song nucleus volume indirectly by acting in the preoptic area, a region regulating sexual behaviors, including song, that connects to the song system through catecholaminergic cells. Seasonal neuroplasticity in the song system involves an interplay among seasonal state, testosterone action, and behavioral activity.