Werner's syndrome – chromosome analyses of cultured fibroblasts and mitogen‐stimulated lymphocytes
Werner's syndrome – chromosome analyses of cultured fibroblasts and mitogen‐stimulated lymphocytes
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维尔纳综合征 – 培养的成纤维细胞和有丝分裂原刺激的淋巴细胞的染色体分析
DOI：
10.1046/j.1365-2133.1997.6301592.x
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发表时间：
1997
影响因子：
10.3
通讯作者：
S. Imamura
中科院分区：
文献类型：
--
作者：
K. Morita;C. Nishigori;M. Sasaki;N. Matsuyoshi;K. Ohta;H. Okamoto;K. Ikai;S. Imamura
本文报告2例Werner综合征。两例患者的成纤维细胞显示群体倍增数减少。两名患者的成纤维细胞和一名患者的淋巴细胞的染色体分析显示，染色体畸变频繁和随机发生。虽然一些染色体畸变涉及肿瘤抑制基因定位的位点，但我们的患者均未表现出恶性。一个关键位点的染色体畸变可能不足以诱发癌症，或者可能需要其他因素。
Two cases of Werner's syndrome are reported. Fibroblasts derived from both patients revealedreduced population doubling numbers. Chromosomal analyses for fibroblasts from both patients and lymphocytes from one patient revealed that chromosomal aberrations occur frequently and randomly. Although some of the chromosomal aberrations involved sites where tumour suppressor genes have been mapped, neither of our patients demonstrated malignancy. Chromosomal aberration at one critical site may not be sufficient to induce cancer or additional factors may be necessary.