EFFECTS OF INTRADERMAL BRADYKININ AFTER INHIBITION OF ANGIOTENSIN CONVERTING ENZYME
EFFECTS OF INTRADERMAL BRADYKININ AFTER INHIBITION OF ANGIOTENSIN CONVERTING ENZYME
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DOI：
10.1136/bmj.294.6580.1119
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发表时间：
1987-05-02
影响因子：
105.7
通讯作者：
RAWLINS, MD
中科院分区：
文献类型：
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作者：
FERNER, RE;SIMPSON, JM;RAWLINS, MD
血管紧张素转换酶抑制剂可引起血管性水肿。为了观察这是否是由于缓激肽的组织效应的增强，在单剂量的卡托普利、依那普利或安慰剂之前和之后三次测量通过皮内注射盐水或1、3或10 μ g缓激肽而增加的伤痕厚度。平均厚度随缓激肽剂量的增加而增加。在服用安慰剂或卡托普利后，它没有随时间变化，但从依那普利前的0.61 mm增加到依那普利给药后2.5小时的1.12 mm和5小时的1.06 mm。五名受试者在服用开搏通后出现脸红，四名受试者在服用依那普利后出现脸红，但在服用安慰剂后服用缓激肽时没有人出现脸红。它的结论是血管紧张素转换酶抑制剂增强皮内缓激肽在体内的影响，这可能部分解释了为什么他们在易感患者中引起血管性水肿。
Inhibitors of angiotensin converting enzyme may cause angiooedemia. To see if this might be due to potentiation of the tissue effects of bradykinin the thickness of weals raised by intradermal injection of saline or 1, 3, or 10 .mu.g bradykinin was measured before and three times after single doses of captopril, enalapril, or placebo. The mean thickness increased with increasing doses or bradykinin. It did not change with time after the administration of placebo or captopril but increased from 0.61 mm before enalapril to 1.12 mm two and a half hours and 1.06 mm five hours after enalapril was given. Five subjects flushed when given bradykinin after captopril and four after enalapril, but none flushed when given bradykinin after placebo. It is concluded that angiotensin converting enzyme inhibitors potentiate the effects of intradermal bradykinin in vivo and that this may partially explain why they cause angio-oedema in susceptible patients.