Neonates support lymphopenia-induced proliferation
Neonates support lymphopenia-induced proliferation
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DOI：
10.1016/s1074-7613(02)00508-3
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发表时间：
2003-01-01
期刊：
影响因子：
32.4
通讯作者：
Paul, WE
中科院分区：
文献类型：
--
作者：
Min, BK;McHugh, R;Paul, WE
当转移到成人淋巴细胞减少的环境中时，T细胞在没有有意抗原刺激的情况下扩增。在这项研究中，我们表明，生理淋巴细胞减少的环境中存在的新生小鼠也支持CD 4 T细胞增殖。引人注目的是，在新生儿内增殖的幼稚CD 4 T细胞获得记忆细胞的表型和功能特征。这种增殖被记忆和初始CD 4 T细胞的存在抑制，被3天胸腺切除术增强，不依赖于IL-7，并且需要If类MHC-TCR相互作用和CD 28介导的信号。根据VP表达的分布判断，新生儿中的CD 44（亮）CD 4 T细胞具有广泛的库。因此，淋巴细胞减少诱导的T细胞增殖是一个生理过程，发生在出生后早期。
T cells expand without intentional antigen stimulation when transferred into adult lymphopenic environments. In this study, we show that the physiologic lymphopenic environment existing in neonatal mice also supports CD4 T cell proliferation. Strikingly, naive CD4 T cells that proliferate within neonates acquire the phenotypic and functional characteristics of memory cells. Such proliferation is inhibited by the presence of both memory and naive CD4 T cells, is enhanced by 3-day thymectomy, is independent of IL-7, and requires a class If MHC-TCR interaction and a CD28mediated signal. CD44(bright) CD4 T cells in neonates have a wide repertoire as judged by the distribution of VP expression. Thus, lymphopenia-induced T cell proliferation is a physiologic process that occurs during the early postnatal period.