Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery
Maternal anemia during pregnancy is an independent risk factor for low birthweight and preterm delivery
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DOI：
10.1016/j.ejogrb.2005.02.015
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发表时间：
2005-10-01
影响因子：
2.6
通讯作者：
Sheiner, E
中科院分区：
文献类型：
--
作者：
Levy, A;Fraser, D;Sheiner, E
目的：本研究的目的是探讨妊娠和分娩的贫血patients with anemia.Methods的结果：一项回顾性的人口为基础的研究比较所有单胎妊娠的患者和没有贫血进行。1988年至2002年期间，索罗卡大学医学中心发生了多起自杀事件。孕妇贫血定义为妊娠期间血红蛋白浓度低于10 g/dl。血红蛋白病如地中海贫血患者被排除在分析之外。多元Logistic回归模型进行控制confounders.Results：在研究期间有153,396交付，其中13,204（8.6%）发生在贫血患者。在多变量分析中，以下情况与母体贫血显著相关：胎盘早剥、前置胎盘、引产、既往剖宫产（CS）、非头位和贝都因种族。与非贫血妇女相比，贫血妇女的早产（< 37周妊娠）和低出生体重（< 2500 g）发生率较高（分别为10.7%和9.0%，p < 0.001; 10.5%和9.4%，p < 0.001）。贫血妇女CS发生率较高（20.4%对10.3%; P < 0.001）。采用多变量分析（OR = 1.1; 95%CI 1.0-1.2; p = 0.02），在调整性别、种族和胎龄后，贫血和低出生体重之间的显著相关性持续存在。以早产（< 37孕周）和低出生体重（< 2500 g）为结局变量，建立了两个多变量logistic回归模型，以控制可能的混杂因素，如种族、母亲年龄、胎盘问题、分娩方式和非头位先露。母亲贫血是早产（OR = 1.2; 95%CI 1.1-1.2，p < 0.001）和低出生体重（OR = 1.1; 95%CI 1.1-1.2，p = 0.001）的独立危险因素。结论：母亲贫血影响出生体重和早产，但在我们的人群中，与不良围产儿结局无关。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Objective: The present study was designed to investigate the outcome of pregnancy and delivery in patients with anemia.Methods: A retrospective population-based study comparing all singleton pregnancies of patients with and without anemia was performed. Deliveries occurred during the years 1988-2002 in the Soroka University Medical Center. Maternal anemia was defined as hemoglobin concentration lower than 10 g/dl during pregnancy. Patients with hemoglobinopathies such as thalassemia were excluded from the analysis. Multiple logistic regression models were performed to control for confounders.Results: During the study period there were 153,396 deliveries, of which 13,204 (8.6%) occurred in patients with anemia. In a multivariable analysis, the following conditions were significantly associated with maternal anemia: placental abruption, placenta previa, labor induction, previous cesarean section (CS), non-vertex presentation and Bedouin ethnicity. Higher rates of preterm deliveries (< 37 weeks gestation) and low birthweight (< 2500 g) were found among patients with anemia as compared to the non-anemic women (10.7% versus 9.0%, p < 0.001 and 10.5% versus 9.4%, p < 0.001;respectively). Higher rates of CS were found among anemic women (20.4% versus 10.3%; P < 0.001). The significant association between anemia and low birthweight persisted after adjusting for gender, ethnicity and gestational age, using a multivariable analysis (OR = 1.1; 95% Cl 1.0-1.2; p = 0.02). Two multivariable logistic regression models, with preterm delivery (< 37 weeks gestation) and low birthweight (< 2500 g) as the outcome variables, were constructed in order to control for possible confounders such as ethnicity, maternal age, placental problems, mode of delivery and non-vertex presentation. Maternal anemia was an independent risk factor for both, preterm delivery (OR = 1.2; 95% Cl 1.1-1.2, p < 0.001) and low birthweight (OR = 1.1; 95% Cl 1.1-1.2, p = 0.001).Conclusion: Maternal anemia influences birthweight and preterm delivery, but in our population, is not associated with adverse perinatal outcome. (c) 2005 Elsevier Ireland Ltd. All rights reserved.