Association between interleukin 21 and Graves' disease
Association between interleukin 21 and Graves' disease
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白细胞介素 21 与格雷夫斯病之间的关联
DOI：
10.4238/2011.october.31.6
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发表时间：
2011-01-01
影响因子：
0.4
通讯作者：
Zhao, Y. J.
中科院分区：
文献类型：
--
作者：
Jia, H. Y.;Zhang, Z. G.;Zhao, Y. J.
Graves病（GD）是一种器官特异性自身免疫性甲状腺疾病; 25-50%的GD患者会发展为Graves眼病（GO）。GD和GO的病因可能是多因素的，但免疫反应起着核心作用。许多研究已经报道IL-21在自身免疫性疾病中具有关键作用。我们研究了IL-21是否与GD和GO的发展相关。检测40例原发性GD患者、42例经治GO患者和24例健康对照者血清IL-21浓度。我们的数据表明，血清IL-21水平与GD的发展有关。我们还对633例患者和612例健康对照者的IL-21基因多态性rs 4833837、rs 907715和rs 13143866进行了关联研究。该病例对照关联研究表明，rs 907715 SNP与GD显著相关，而rs 13143866 A等位基因与GO显著相关。GD患者中A-G-G和A-A-A的频率分别较高和较低，提示A-A-A具有保护作用。然而，GO患者和对照组之间这些单倍型的频率没有显著差异。我们发现IL-21基因多态性与GD发病年龄之间没有关联。我们得出结论，IL-21与GD和GO相关。
Graves' disease (GD) is an organ-specific autoimmune thyroid disease; 25-50% of GD patients will develop Graves' ophthalmopathy (GO). The etiology of GD and GO may be multifactorial, but the immune response plays a central role. Many studies have reported that IL-21 has crucial roles in autoimmune diseases. We examined whether IL-21 is associated with the development of GD and GO. The serum concentration of IL-21 was tested in 40 primary GD patients, 42 treated GO patients and 24 healthy controls. Our data show that the serum level of IL-21 is associated with the development of GD. We also made an association study with the IL-21 gene polymorphisms rs4833837, rs907715 and rs13143866 in a comparison of 633 patients and 612 healthy controls from the Chinese population. This case-control association study demonstrated that rs907715 SNP is significantly associated with GD, while the rs13143866 A allele is significantly associated with GO. The haplotypes A-G-G and A-A-A were found at higher and lower frequencies, respectively, in GD patients, suggesting a protective role for A-A-A. However, there were no significant differences in the frequencies of these haplotypes between the GO patients and the control group. We found no association between IL-21 gene polymorphisms and the age of GD onset. We conclude that IL-21 is associated with GD and GO.