Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward
Role of noradrenergic signaling by the nucleus tractus solitarius in mediating opiate reward
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DOI：
10.1126/science.1119311
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发表时间：
2006-02-17
期刊：
影响因子：
56.9
通讯作者：
Palmiter, RD
中科院分区：
文献类型：
--
作者：
Olson, VG;Heusner, CL;Palmiter, RD
去甲肾上腺素（NE）广泛参与阿片类药物戒断，但其在阿片类药物诱导的运动和奖赏中的作用知之甚少。在缺乏多巴胺β-羟化酶（DBH）（NE合成的关键酶）的小鼠中，我们发现NE对于吗啡诱导的条件性位置偏爱（CPP;奖赏的量度）和运动是必需的。这些缺陷被全身NE恢复所挽救。病毒恢复DBH表达的孤束核，但不是在蓝斑，恢复吗啡的CPP。吗啡诱导的运动部分恢复DBH表达在任何一个大脑区域。这些数据表明，NE信号由孤束核是必要的吗啡奖励。
Norepinephrine (NE) is widely implicated in opiate withdrawal, but much less is known about its role in opiate-induced locomotion and reward. in mice lacking dopamine beta-hydroxytase (DBH), an enzyme critical for NE synthesis, we found that NE was necessary for morphine-induced conditioned place preference (CPP; a measure of reward) and locomotion. These deficits were rescued by systemic NE restoration. Viral restoration of DBH expression in the nucleus tractus solitarius, but not in the locus coeruleus, restored CPP for morphine. Morphine-induced locomotion was partially restored by DBH expression in either brain region. These data suggest that NE signaling by the nucleus tractus solitarius is necessary for morphine reward.