Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression
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DOI：
10.1126/science.288.5469.1254
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发表时间：
2000-05-19
期刊：
影响因子：
56.9
通讯作者：
Bear, MF
中科院分区：
文献类型：
--
作者：
Huber, KM;Kayser, MS;Bear, MF
一个海马锥体神经元接收超过10⁴个兴奋性谷氨酸能突触。这些突触中的许多都包含信使RNA翻译的分子机制，这表明每个突触的蛋白质组成（以及因此的功能）可以根据活动进行调节。在此，由代谢型谷氨酸受体的突触激活所触发的局部突触后蛋白质合成被发现可在数分钟内改变突触传递。
A hippocampal pyramidal neuron receives more than 10(4) excitatory glutamatergic synapses. Many of these synapses contain the molecular machinery for messenger RNA translation, suggesting that the protein complement (and thus function) of each synapse can be regulated on the basis of activity. Here, Local postsynaptic protein synthesis, triggered by synaptic activation of metabotropic glutamate receptors, was found to modify synaptic transmission within minutes.