THE TOPOGRAPHY OF EXPANDED UNCROSSED RETINAL PROJECTIONS FOLLOWING NEONATAL ENUCLEATION OF ONE EYE - DIFFERING EFFECTS IN DORSAL LATERAL GENICULATE-NUCLEUS AND SUPERIOR COLLICULUS
THE TOPOGRAPHY OF EXPANDED UNCROSSED RETINAL PROJECTIONS FOLLOWING NEONATAL ENUCLEATION OF ONE EYE - DIFFERING EFFECTS IN DORSAL LATERAL GENICULATE-NUCLEUS AND SUPERIOR COLLICULUS
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DOI：
10.1002/cne.902500103
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发表时间：
1986-08-01
影响因子：
2.5
通讯作者：
REESE, BE
中科院分区：
文献类型：
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作者：
REESE, BE
本文研究了正常成年大鼠和出生后单侧眼球摘除大鼠视网膜向外侧膝状体背侧核（dLGN）和上级丘（SC）的非交叉投射的局部组织结构。在不同位置的离散视网膜病变后，对切片进行顺行变性产物染色。从颞叶新月形的dLGN在nasotemporal摘除大鼠的投影有一个扩大，但地形正常的组织，与nasotemporal和背腹侧视网膜轴显示极性相同的正常成年人。新生儿眼球摘除术允许剩余的未交叉的视网膜小膝体投射主要沿着“投射线”延伸到通常接受双眼共轭交叉投射的神经元。在SC，背腹轴的颞新月显示了正常的极性，但鼻颞轴未能显示任何地形组织。视网膜位点在颞新月形投影在同侧SC的整个吻尾向范围内。视网膜病变放置在颞新月形以外未能产生任何实质性的变性在同侧dLGN或SC。这些地形上不同的影响，在dLGN和SC后，在出生当天的单眼切除的背景下，在不同的限制轴突向内生长和连接在早期发展，其通常可导致视网膜小膝状体和视网膜丘组织的特征性不同特征。
The topographic organization of the uncrossed retinal projections to the dorsal lateral geniculate nucleus (dLGN) and superior colliculus (SC) was studied in normal adult hooded rats and in rats subjected to unilateral ocular enucleation on the day of birth. Sections were stained for anterograde degeneration products following discrete retinal lesions at various locations. The projection from the temporal crescent to the dLGN in neonatally enucleated rats had an expanded but topographically normal organization, with the nasotemporal and dorsoventral retinal axes displaying polarities identical to those in normal adults. Neonatal enucleation permits the remaining uncrossed retinogeniculate projection to extend primarily along the "lines of projection" into neuropil normally recipient of binocularly conjugate crossed projections. In the SC, the dorsoventral axis of the temporal cresecent showed a normal polarity, but the nasotemporal axis failed to display any topographic organization. Retinal loci in the temporal crescent projected throughout the rostrocaudal extent of the ipsilateral SC. Retinal lesions placed outside the temporal crescent failed to produce any substantial degeneration in ipsilateral dLGN or SC. These topographically distinct effects in dLGN and SC following unilateral eye removal on the day of birth are discussed in the context of differing constraints upon axonal ingrowth and connectivity during early development, which may normally bring about the characteristically distinct features of retinogeniculate and retinocollicular organization.