mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with Native Americans.
mtDNA variation of aboriginal Siberians reveals distinct genetic affinities with Native Americans.
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发表时间：
1993-09
影响因子：
9.8
通讯作者：
A. Torroni;R. Sukernik;T. Schurr;B. Starikovskaya;Margaret F. Cabell;M. Crawford;A. Comuzzie;D. Wallace
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文献类型：
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作者：
A. Torroni;R. Sukernik;T. Schurr;B. Starikovskaya;Margaret F. Cabell;M. Crawford;A. Comuzzie;D. Wallace
本文分析了10个西伯利亚原住民群体的411个个体的mtDNA变异，试图揭示西伯利亚原住民群体与美洲原住民群体之间的关系。所有的mtDNA的特征在于通过PCR扩增和限制性内切酶分析，其中一个子集的特征在于通过控制区测序。然后将所得数据与先前来自美洲原住民和亚洲人的mtDNA数据进行汇编，并用于系统发育分析和序列分歧估计。西伯利亚原住民的mtDNA来自美洲原住民中观察到的四个单倍群中的三个（A、C和D）。然而，没有一个西伯利亚人群显示来自第四单倍型群B群的mtDNA。B组缺失单倍型在东亚和美洲土著人群中的存在，而在西伯利亚人群中的缺失，提出了这样一种可能性，即单倍型组B可能代表了一个与将A、C和D组mtDNA带到美洲的事件不同的迁移事件。我们的研究结果支持了这样的假设，即第一批从西伯利亚迁移到美洲的人类携带了有限数量的创始mtDNA，并且最初的迁移发生在距今17，000 - 34，000年之前。
The mtDNA variation of 411 individuals from 10 aboriginal Siberian populations was analyzed in an effort to delineate the relationships between Siberian and Native American populations. All mtDNAs were characterized by PCR amplification and restriction analysis, and a subset of them was characterized by control region sequencing. The resulting data were then compiled with previous mtDNA data from Native Americans and Asians and were used for phylogenetic analyses and sequence divergence estimations. Aboriginal Siberian populations exhibited mtDNAs from three (A, C, and D) of the four haplogroups observed in Native Americans. However, none of the Siberian populations showed mtDNAs from the fourth haplogroup, group B. The presence of group B deletion haplotypes in East Asian and Native American populations but their absence in Siberians raises the possibility that haplogroup B could represent a migratory event distinct from the one(s) which brought group A, C, and D mtDNAs to the Americas. Our findings support the hypothesis that the first humans to move from Siberia to the Americas carried with them a limited number of founding mtDNAs and that the initial migration occurred between 17,000-34,000 years before present.